DCAKD and VPS25

		DCAKD	VPS25
Description		dephospho-CoA kinase domain containing	vacuolar protein sorting 25 homolog
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Membrane	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Dephospho-CoA Kinase Activity ATP Binding	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Coenzyme A Biosynthetic Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission
Pathways		Coenzyme A biosynthesis	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Asthma ( 31619474) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Craniofacial microsomia ( 26853712) Heel bone mineral density ( 30598549) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes			24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36
Entrez ID		79877	84313
HPRD ID		08012	14396
Ensembl ID		ENSG00000172992	ENSG00000131475
Uniprot IDs		Q8WVC6	Q9BRG1
PDB IDs			2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?			Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport
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