ING5 and MCM6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		ING5	MCM6
Gene Name		inhibitor of growth family, member 5	minichromosome maintenance complex component 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex	Nucleus Nucleoplasm MCM Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Methylated Histone Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	DNA Replication Chromatin Organization Transcription, DNA-templated Protein Acetylation Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: APC APLP1 ARFIP2 BARD1 C3orf62 CCDC33 CCDC67 CDCA7L CDKN1A CEP44 EP300 FAM118B GCSH HAP1 HGS HTT ICA1 IKZF3 JADE2 KIAA1377 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 PCM1 PRMT5 SMARCE1 TADA3 TAF1D TP53 VIM	31 interactors: ALS2CR11 CCNA1 CDC45 CDC7 CDKN2A CDT1 CRLS1 DBF4 FAM161A GMNN HDAC1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MLLT3 NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 ZBTB9
Entrez ID		84289	4175
HPRD ID		16348	03485
Ensembl ID		ENSG00000168395	ENSG00000076003
Uniprot IDs		Q8WYH8	Q14566
PDB IDs		3C6W	2KLQ 2LE8
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Organelle Organization Chromosome Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cell Cycle Regulation Of Tubulin Deacetylation Histone Acetylation Mitotic Cell Cycle Phase Transition Internal Peptidyl-lysine Acetylation Cell Cycle Phase Transition Peptidyl-lysine Acetylation Cytoplasmic Microtubule Organization Chromatin Organization Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Gene Expression Cell Cycle Arrest Histone H3 Acetylation Regulation Of Protein Deacetylation Circadian Rhythm Chromatin Modification Stress-induced Premature Senescence Histone Modification Cell Aging Apoptotic Process Negative Regulation Of Gene Expression Tissue Development Central Nervous System Development Regulation Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Mitotic Cell Cycle Arrest Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Cell Cycle Phase Transition Cell Death Death Nervous System Development Epithelium Development Determination Of Adult Lifespan	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Chromosome Organization Cellular Metabolic Process DNA Conformation Change Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Cellular Response To Stress Regulation Of Nuclear Cell Cycle DNA Replication DNA Replication Checkpoint Cellular Process Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint DNA Recombination Organelle Organization Negative Regulation Of Cell Cycle
Tagcloud ?		acetylates acetyllysine bonding bromodomain brpf1 calculate directs discrete energies finger h2a h2ak5ac h2b h3k14ac h4k12ac hat heaf6 histones monocytic moz outline perturbation phd pocket quaternary selects tails titration translationally	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?		acetylates acetyllysine bonding bromodomain brpf1 calculate directs discrete energies finger h2a h2ak5ac h2b h3k14ac h4k12ac hat heaf6 histones monocytic moz outline perturbation phd pocket quaternary selects tails titration translationally	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?