ING5 and ICA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ING5	ICA1
Description		inhibitor of growth family member 5	islet cell autoantigen 1
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome MOZ/MORF Histone Acetyltransferase Complex	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity
	Biological Process	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Organization Regulation Of DNA-templated Transcription Protein Acetylation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Developmental Process Regulation Of Cell Cycle Apoptotic Signaling Pathway DNA Replication-dependent Chromatin Disassembly Regulation Of Hemopoiesis Regulation Of DNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway	Neurotransmitter Transport Regulation Of Secretion Membrane Bending
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Asthma ( 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Platelet distribution width ( 32888494)	Cognitive function ( 24684796) Intraocular pressure ( 23836780) Metabolite levels (Pyroglutamine) ( 23934736) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 28714469)
Interacting Genes		45 interacting genes: APC APLP1 ARFIP2 BARD1 BEX3 C3orf62 CBY2 CCDC33 CCHCR1 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH GGA1 GRIPAP1 HAP1 HGS HTT ICA1 IKZF3 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 ODF2 PCM1 PRMT5 RCOR3 SMARCE1 SUOX TADA3 TAF1D THAP6 TP53 TRIML2 VIM WASF1	9 interacting genes: CCDC28A EXOC5 ING5 MBD3 RAB2A RAB2B SHANK3 SNCA TSC1
Entrez ID		84289	3382
HPRD ID		16348	00971
Ensembl ID		ENSG00000168395	ENSG00000003147
Uniprot IDs		A0A1B0GW41 Q8WYH8	A0A024RA29 Q05084
PDB IDs		3C6W 5ME8 5MTO
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Centriole Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Protein Binding Cytosol Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Domain Specific Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Centriole Replication P53 Binding Membrane Curvature Sensor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Organization Centriole Assembly Organelle Transport Along Microtubule Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transport Along Microtubule Regulation Of Cell Cycle G1/S Phase Transition Stress-induced Premature Senescence Protein-containing Complex Cytoskeleton-dependent Intracellular Transport Intracellular Transport Regulation Of Organelle Organization Microtubule-based Process Negative Regulation Of Mitotic Cell Cycle Nuclear Receptor Binding Neurogenesis Regulation Of Mitotic Cell Cycle Phase Transition Centrosome Regulation Of DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Microtubule-based Transport Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Cyclin-dependent Protein Kinase Activity Nucleoplasm Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centriole-centriole Cohesion Regulation Of Intracellular Protein Transport ATAC Complex Cellular Senescence Regulation Of Intracellular Transport Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Replicative Senescence	Autophagosome Membrane Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Adult Behavior Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Synapse Organization Memory T Cell Differentiation Acrosomal Vesicle Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Adult Locomotory Behavior Transporter Regulator Activity Regulation Of Norepinephrine Uptake Regulation Of Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Cell Junction Organization Regulation Of Cell Size TSC1-TSC2 Complex Associative Learning DNA Replication-dependent Chromatin Disassembly Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Golgi Organization Vesicle-mediated Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Synaptic Receptor Adaptor Activity Regulation Of Cytoskeleton Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Synaptic Transmission ATPase Inhibitor Activity Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Macroautophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Learning Response To Bisphenol A
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