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HDHD2 and DVL1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
HDHD2
DVL1
Gene Name
haloacid dehalogenase-like hydrolase domain containing 2
dishevelled segment polarity protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Vesicular Exosome
Cytoplasm
Cytosol
Microtubule
Cytoplasmic Membrane-bounded Vesicle
Lateral Plasma Membrane
Clathrin-coated Vesicle
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuronal Cell Body
Synapse
Molecular Function
Enzyme Binding
Metal Ion Binding
Molecular_function
Frizzled Binding
Protein Binding
Enzyme Binding
Protein Kinase Binding
Identical Protein Binding
Rac GTPase Binding
Biological Process
Biological_process
Regulation Of Neurotransmitter Levels
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Protein Kinase Activity
Neurotransmitter Secretion
Axon Guidance
Heart Development
Neuromuscular Junction Development
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Neural Tube Development
Convergent Extension Involved In Neural Plate Elongation
Positive Regulation Of Wnt Signaling Pathway
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Social Behavior
Protein Localization To Microtubule
Intracellular Signal Transduction
Receptor Clustering
Positive Regulation Of Transcription, DNA-templated
Collateral Sprouting
Axon Extension
Dendrite Morphogenesis
Synapse Organization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Prepulse Inhibition
Skeletal Muscle Acetylcholine-gated Channel Clustering
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT mediated activation of DVL
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
negative regulation of TCF-dependent signaling by DVL-interacting proteins
Signaling by Wnt
Signaling by WNT in cancer
PCP/CE pathway
beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
12 interactors:
BAI2
CFD
CRMP1
DVL1
EPHB6
LUC7L2
MEOX2
MGST2
PIP5K1C
SOD2
TARBP2
TRAPPC11
35 interactors:
ANXA7
ARRB1
ATN1
AXIN1
BRD7
CCDC88C
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
CXXC4
DAAM1
DAB2
DVL3
DYNLT1
EPS8
FRAT1
HDHD2
HECW1
LRRK2
NCK2
NEDD4
PPM1A
PSMA3
RAC1
SIPA1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
TRIM69
USP13
VANGL1
VANGL2
Entrez ID
84064
1855
HPRD ID
13640
03220
Ensembl ID
ENSG00000167220
ENSG00000107404
Uniprot IDs
Q9H0R4
O14640
Q86TH3
PDB IDs
3HLT
Enriched GO Terms of Interacting Partners
?
Axon Guidance
Neuron Development
Axonogenesis
Response To External Stimulus
Axon Development
Neuron Differentiation
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Neuron Projection Morphogenesis
Cell Morphogenesis Involved In Differentiation
Nervous System Development
Erythrophore Differentiation
Age-dependent Response To Reactive Oxygen Species
Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure
Neuron Projection Development
Glutathione Metabolic Process
Cell Projection Morphogenesis
Generation Of Neurons
Cell Part Morphogenesis
Neurogenesis
MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA
Cell Development
Neurotransmitter Secretion
Cell Morphogenesis
Convergent Extension Involved In Neural Plate Elongation
Targeting Of MRNA For Destruction Involved In RNA Interference
Response To Silicon Dioxide
Response To Magnetism
System Development
Secretion By Cell
Cell Projection Organization
Regulation Of Neurotransmitter Levels
Collateral Sprouting
Age-dependent Response To Oxidative Stress
Production Of SiRNA Involved In RNA Interference
Detection Of Oxygen
Peptide Metabolic Process
Locomotion
Convergent Extension Involved In Organogenesis
Somite Specification
Response To Selenium Ion
Ribonucleoprotein Complex Assembly
Neurotransmitter Transport
Secretion
Multicellular Organismal Development
Oxygen Homeostasis
Pyrimidine Nucleobase Catabolic Process
Protein Localization To Microtubule
Platelet Activation
RNA Interference
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Regulation Of Cell Morphogenesis
Regulation Of Signaling
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Canonical Wnt Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Embryonic Pattern Specification
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Modification Process
SMAD Protein Complex Assembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cellular Metabolic Process
Signaling
Regulation Of Proteasomal Protein Catabolic Process
Cell Communication
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Cellular Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Positive Regulation Of Stem Cell Differentiation
Embryonic Axis Specification
Regulation Of Phosphorus Metabolic Process
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Kidney Development
Tagcloud
?
1p36
1q36
20p12
2q37
accumulating
boy
brachydactyly
chr1
chr2
chr20
cnv
cnvs
coarctation
deleted
deletion
digit
duplications
dysmorphism
facial
gpcpd1
hdac4
intellectual
malformations
p36
pcrs
phenotypes
simply
syndromic
tumorigenic
Tagcloud (Difference)
?
1p36
1q36
20p12
2q37
accumulating
boy
brachydactyly
chr1
chr2
chr20
cnv
cnvs
coarctation
deleted
deletion
digit
duplications
dysmorphism
facial
gpcpd1
hdac4
intellectual
malformations
p36
pcrs
phenotypes
simply
syndromic
tumorigenic
Tagcloud (Intersection)
?