HDHD2 and SOD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		HDHD2	SOD2
Gene Name		haloacid dehalogenase-like hydrolase domain containing 2	superoxide dismutase 2, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Enzyme Binding Metal Ion Binding	DNA Binding Superoxide Dismutase Activity Oxygen Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Biological_process	Response To Reactive Oxygen Species Response To Superoxide Age-dependent Response To Reactive Oxygen Species Response To Hypoxia Release Of Cytochrome C From Mitochondria Liver Development Detection Of Oxygen Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription From RNA Polymerase II Promoter Glutathione Metabolic Process Superoxide Metabolic Process Heart Development Locomotory Behavior Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Cold Post-embryonic Development Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Response To Gamma Radiation Response To Activity Removal Of Superoxide Radicals Respiratory Electron Transport Chain Hemopoiesis Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Response To Isolation Stress Response To Immobilization Stress Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Response To Cadmium Ion Negative Regulation Of Fibroblast Proliferation Neuron Development Response To Axon Injury Erythrophore Differentiation Hydrogen Peroxide Biosynthetic Process Regulation Of Catalytic Activity Protein Homotetramerization Response To Electrical Stimulus Regulation Of Mitochondrial Membrane Potential Iron Ion Homeostasis Response To Hyperoxia Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways			Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS			Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		12 interactors: BAI2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11	8 interactors: APP CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		84064	6648
HPRD ID		13640	00938
Ensembl ID		ENSG00000167220	ENSG00000112096
Uniprot IDs		Q9H0R4	P04179
PDB IDs		3HLT	1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T
Enriched GO Terms of Interacting Partners?		Axon Guidance Neuron Development Axonogenesis Response To External Stimulus Axon Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Nervous System Development Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Neuron Projection Development Glutathione Metabolic Process Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cell Development Neurotransmitter Secretion Cell Morphogenesis Convergent Extension Involved In Neural Plate Elongation Targeting Of MRNA For Destruction Involved In RNA Interference Response To Silicon Dioxide Response To Magnetism System Development Secretion By Cell Cell Projection Organization Regulation Of Neurotransmitter Levels Collateral Sprouting Age-dependent Response To Oxidative Stress Production Of SiRNA Involved In RNA Interference Detection Of Oxygen Peptide Metabolic Process Locomotion Convergent Extension Involved In Organogenesis Somite Specification Response To Selenium Ion Ribonucleoprotein Complex Assembly Neurotransmitter Transport Secretion Multicellular Organismal Development Oxygen Homeostasis Pyrimidine Nucleobase Catabolic Process Protein Localization To Microtubule Platelet Activation RNA Interference	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Pressure Natriuresis Vitamin K Biosynthetic Process Membrane Organization Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization Establishment Of Protein Localization To Membrane Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Vitamin K Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Long-chain Fatty Acid Catabolic Process Protein Insertion Into ER Membrane Neuron Remodeling Cellular Protein Localization Protein Localization To Membrane
Tagcloud ?			arbitrary biogenesis catalase centrally damages dihydroethidium dw femoral hypoperfusion iliac ligatures methoxyisobutylisonitrile mibi mimicking minute mmol muscles myopathic paramagnetic pgc proliferator respiration rounded scintigraphic scintigraphies submitted swiss vmax wider
Tagcloud (Difference) ?			arbitrary biogenesis catalase centrally damages dihydroethidium dw femoral hypoperfusion iliac ligatures methoxyisobutylisonitrile mibi mimicking minute mmol muscles myopathic paramagnetic pgc proliferator respiration rounded scintigraphic scintigraphies submitted swiss vmax wider
Tagcloud (Intersection) ?