GATAD2A and KRT32

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GATAD2A	KRT32
Description		GATA zinc finger domain containing 2A	keratin 32
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome NuRD Complex Nuclear Speck	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Metal Ion Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 31562340 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mild age-related type 2 diabetes ( 34737425) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		15 interacting genes: CBFA2T3 CEBPA CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 PAK4 SPOP	17 interacting genes: CCDC187 GATAD2A KIFC3 KRT2 KRT3 KRT5 KRT6B KRT72 KRT75 KRT76 KRT78 KRT8 KRT80 KRT86 NEDD9 TCHP UBASH3A
Entrez ID		54815	3882
HPRD ID		11741	04134
Ensembl ID		ENSG00000167491	ENSG00000108759
Uniprot IDs		Q86YP4	Q14532
PDB IDs		2L2L
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization N-terminal Peptidyl-lysine Acetylation Structural Constituent Of Chromatin Nucleosome Chromosome Response To Nutrient Levels Epigenetic Regulation Of Gene Expression Response To Bisphenol A Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Intermediate Filament Organization Ventricular Cardiac Muscle Tissue Development Regulation Of DNA Repair Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process NuRD Complex Acetyltransferase Activity Protein-containing Complex Nucleosome Assembly Hematopoietic Stem Cell Proliferation Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Methyl-CpG Binding Nucleosome Organization Granulocyte Differentiation Positive Regulation Of DNA Repair Histone Acetyltransferase Activity Heterochromatin Formation Protein Acetylation DNA Methylation-dependent Constitutive Heterochromatin Formation Intermediate Filament Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Nucleosomal DNA Binding Inositol-3-phosphate Synthase Activity Nucleoplasm DNA-binding Transcription Factor Binding Structural Molecule Activity Protein-DNA Complex Assembly Heterochromatin Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Glycolytic Process Response To Vitamin B2	Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Intermediate Filament Cytoskeleton Cytosol Structural Constituent Of Cytoskeleton Epidermis Development Desmosome Intermediate Filament Polymerization Cornified Envelope Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Positive Regulation Of Immunological Synapse Formation Scaffold Protein Binding Zonula Adherens Maintenance
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