GATAD2A and MBD2

Number of citations of the paper that reports this interaction (PMID 12183469)
20

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		GATAD2A	MBD2
Gene Name		GATA zinc finger domain containing 2A	methyl-CpG binding domain protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm NuRD Complex Nuclear Speck	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Protein Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Binding, Bridging Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Neural Fold Formation DNA Methylation Transcription, DNA-templated Embryonic Body Morphogenesis Programmed Cell Death Anterior Neuropore Closure Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Positive Regulation Of Wnt Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Cellular Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance	NoRC negatively regulates rRNA expression RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: HDAC1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE KAT2B KRT40 MBD2 MBD3 PAK4	14 interactors: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A
Entrez ID		54815	8932
HPRD ID		11741	04647
Ensembl ID		ENSG00000167491	ENSG00000134046
Uniprot IDs		Q86YP4	Q9UBB5
PDB IDs		2L2L	2L2L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Chromosome Organization Chromatin Silencing Organelle Organization Chromatin Modification DNA Replication-dependent Nucleosome Assembly Gene Silencing Histone Modification DNA Methylation On Cytosine Nucleosome Assembly Chromatin Assembly Chromatin Silencing At RDNA Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging Negative Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification DNA Conformation Change DNA Methylation Protein Complex Assembly DNA Modification Gene Expression Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation N-terminal Peptidyl-lysine Acetylation Histone H4-K20 Demethylation Notch Signaling Pathway Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Megakaryocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process	ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Modification Chromosome Organization Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Gene Expression Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylation Cellular Response To Heat Protein Deacetylation Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Embryonic Digit Morphogenesis Fungiform Papilla Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Eyelid Development In Camera-type Eye Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Hair Follicle Placode Formation Response To Heat Tongue Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Histone H4 Deacetylation
Tagcloud ?			additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve
Tagcloud (Difference) ?			additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve
Tagcloud (Intersection) ?