GATAD2A and PAK4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		GATAD2A	PAK4
Gene Name		GATA zinc finger domain containing 2A	p21 protein (Cdc42/Rac)-activated kinase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm NuRD Complex Nuclear Speck	Golgi Apparatus Focal Adhesion
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Binding, Bridging Sequence-specific DNA Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Neural Fold Formation DNA Methylation Transcription, DNA-templated Embryonic Body Morphogenesis Programmed Cell Death Anterior Neuropore Closure Negative Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Signal Transduction Cell Proliferation Cell Growth Cell Migration Signal Transduction By Phosphorylation Intracellular Signal Transduction
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance	Axon guidance Activation of Rac Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: HDAC1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE KAT2B KRT40 MBD2 MBD3 PAK4	19 interactors: APP CDC42 DLST FBXO25 FGFR2 GATAD2A GRB2 ITGAV ITGB5 LIMK1 POT1 RAN SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ
Entrez ID		54815	10298
HPRD ID		11741	05675
Ensembl ID		ENSG00000167491	ENSG00000130669
Uniprot IDs		Q86YP4	O96013
PDB IDs		2L2L	2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4L67
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Chromosome Organization Chromatin Silencing Organelle Organization Chromatin Modification DNA Replication-dependent Nucleosome Assembly Gene Silencing Histone Modification DNA Methylation On Cytosine Nucleosome Assembly Chromatin Assembly Chromatin Silencing At RDNA Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging Negative Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Negative Regulation Of Biosynthetic Process Histone H3-K9 Modification DNA Conformation Change DNA Methylation Protein Complex Assembly DNA Modification Gene Expression Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation N-terminal Peptidyl-lysine Acetylation Histone H4-K20 Demethylation Notch Signaling Pathway Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Megakaryocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process	Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Innate Immune Response Positive Regulation Of Cell Cycle Axonogenesis Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune Response Axon Development Defense Response Developmental Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Neuron Projection Morphogenesis Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Establishment Of Golgi Localization Anatomical Structure Development Anatomical Structure Formation Involved In Morphogenesis Cell Death Death Axon Guidance Regulation Of Cell Death Cell Differentiation Positive Regulation Of Mitochondrion Organization Cell Morphogenesis Involved In Differentiation Blood Coagulation Hemostasis Signal Transduction Negative Regulation Of Catalytic Activity Nervous System Development Regulation Of Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Telomerase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Intracellular Transport Cell Projection Morphogenesis Regulation Of ERBB Signaling Pathway
Tagcloud ?			apc axin1 cadherin catenin ck1 colon destruction du145 elucidate emt frat1 gsk3beta ht29 inhibiting involves localization maintaining mesenchymal modulate ndrg1 precise prevents ser33 thr41 transforming translocation transporter upregulation wnt
Tagcloud (Difference) ?			apc axin1 cadherin catenin ck1 colon destruction du145 elucidate emt frat1 gsk3beta ht29 inhibiting involves localization maintaining mesenchymal modulate ndrg1 precise prevents ser33 thr41 transforming translocation transporter upregulation wnt
Tagcloud (Intersection) ?