DFFA and AGO2

Number of citations of the paper that reports this interaction (PubMedID 36528617)
61

Data Source:
BioGRID (two hybrid)

		DFFA	AGO2
Description		DNA fragmentation factor subunit alpha	argonaute RISC catalytic component 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein Folding Chaperone Deoxyribonuclease Inhibitor Activity	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism SiRNA Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding
	Biological Process	Apoptotic DNA Fragmentation Protein Folding Apoptotic Process Negative Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation	Regulation Of DNA-templated Transcription Translation Translational Initiation Regulation Of Translation Post-embryonic Development Gene Expression MiRNA Metabolic Process Positive Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing P-body Assembly Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process RNA Stabilization Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RISC Complex Assembly Regulation Of Synapse Maturation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration
Pathways		Apoptosis induced DNA fragmentation	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Male-pattern baldness ( 28196072 29146897)	Age-related hearing impairment ( 34108613) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multisite chronic pain ( 33830993) Neurociticism ( 29500382) Type 1 diabetes ( 34012112)
Interacting Genes		12 interacting genes: AGO2 CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ	35 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DFFA DHX58 DICER1 GEMIN4 HIF1A-AS2 ITCH KAT5 LINC00467 MAPKAPK2 MIR145 MIR19A MIR223 MIR24-1 MIRLET7B MIRLET7I NSD2 PFKP PRKRA PSMC3 RAD51 RBBP6 RNF31 SNCA TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBC ZNF415
Entrez ID		1676	27161
HPRD ID		03531	06943
Ensembl ID		ENSG00000160049	ENSG00000123908
Uniprot IDs		O00273	Q9UKV8
PDB IDs		1IBX 1IYR 1KOY	3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4 7C6B 7D7U 7KI3 8D6J 8D71 8THQ 9BEZ 9BF0 9BF2 9CMP
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Cellular Response To Staurosporine Pyroptotic Inflammatory Response Cell Death Apoptotic Process Programmed Cell Death Protein Domain Specific Binding Fibroblast Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Positive Regulation Of Immune Response To Tumor Cell Regulation Of Amyloid Precursor Protein Biosynthetic Process Aspartic-type Endopeptidase Activity Regulation Of Primary Metabolic Process Regulation Of Synapse Maturation Peptidase Activity Plasma Membrane Repair Regulation Of Response To Tumor Cell Negative Regulation Of Translation Cellular Response To Alkaloid Regulation Of Glycoprotein Biosynthetic Process Hydrolase Activity Cytoplasm Protein Sequestering Activity Leukocyte Apoptotic Process Neuron Recognition Glutamatergic Synapse Negative Regulation Of Translational Initiation Postsynapse Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Ceramide Biosynthetic Process Identical Protein Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Regulation Of Metabolic Process Proteolysis Cysteine-type Endopeptidase Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Synapse Organization Striated Muscle Cell Differentiation Response To External Biotic Stimulus Phospholipase A2 Activator Activity Cytolytic Granule Lumen Leukocyte Mediated Cytotoxicity Synaptic Target Recognition Endoribonuclease Activity, Cleaving MiRNA-paired MRNA Negative Regulation Of G Protein-coupled Receptor Internalization	RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Catabolic Process Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process RISC-loading Complex MRNA Destabilization RNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Biosynthetic Process RISC Complex Assembly Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of MRNA Stability Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of RNA Stability Pre-miRNA Processing Positive Regulation Of MRNA Metabolic Process Response To External Biotic Stimulus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cytokine Production SiRNA Processing Double-stranded RNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Immune Response-activating Signaling Pathway Pre-miRNA Binding MiRNA Processing Regulation Of Defense Response Positive Regulation Of Immune Response Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Pattern Recognition Receptor Signaling Pathway SiRNA Binding Regulation Of Gene Expression Response To Other Organism Immune Response-regulating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Immune System Process Activation Of Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response Regulation Of Macromolecule Biosynthetic Process Immune System Process
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