DFFA

Gene Name		DNA fragmentation factor, 45kDa, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Lipid Particle Cytosol
	Molecular Function	Protein Binding
	Biological Process	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation
Pathways		Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-protein Interactions		11 interactors: CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ
Entrez ID		1676
HPRD ID		03531
Ensembl ID
Uniprot IDs		O00273
PDB IDs		1IBX 1IYR 1KOY
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Protein Processing Activation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Zymogen Activation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Positive Regulation Of Organelle Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic DNA Fragmentation Positive Regulation Of Peptidase Activity Intracellular Signal Transduction Cytolysis Apoptotic Nuclear Changes Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Proteolysis Regulation Of Organelle Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cellular Component Organization DNA Catabolic Process, Endonucleolytic Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Catabolic Process Golgi Reassembly Apoptotic Chromosome Condensation Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization
Tagcloud ?		cd40 cd71 dysplastic effector erythroid erythropoiesis etv6 fas glya gm hematopoiesis hemoglobin ineffective leukemic making megakaryocyte meps microrna mir9 mirna mirnas profiling progenitors robust runx1 sorted speculating sub ut