DFFA and GZMB

Number of citations of the paper that reports this interaction (PubMedID 11406587)
75

Data Source:
HPRD (in vivo, in vitro)

		DFFA	GZMB
Description		DNA fragmentation factor subunit alpha	granzyme B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Immunological Synapse Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Cytolytic Granule Cytolytic Granule Lumen
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein Folding Chaperone Deoxyribonuclease Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Apoptotic DNA Fragmentation Protein Folding Apoptotic Process Negative Regulation Of Deoxyribonuclease Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation	Plasma Membrane Repair Positive Regulation Of Immune Response To Tumor Cell Proteolysis Apoptotic Process Protein Secretion Negative Regulation Of Translation Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Ceramide Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Pyroptotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Pathways		Apoptosis induced DNA fragmentation	NOTCH2 intracellular domain regulates transcription Pyroptosis Activation, myristolyation of BID and translocation to mitochondria Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Male-pattern baldness ( 28196072 29146897)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Interleukin-10 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Vitiligo ( 20410501 27723757)
Interacting Genes		12 interacting genes: AGO2 CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		1676	3002
HPRD ID		03531	00476
Ensembl ID		ENSG00000160049	ENSG00000100453
Uniprot IDs		O00273	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		1IBX 1IYR 1KOY	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Cellular Response To Staurosporine Pyroptotic Inflammatory Response Cell Death Apoptotic Process Programmed Cell Death Protein Domain Specific Binding Fibroblast Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Positive Regulation Of Immune Response To Tumor Cell Regulation Of Amyloid Precursor Protein Biosynthetic Process Aspartic-type Endopeptidase Activity Regulation Of Primary Metabolic Process Regulation Of Synapse Maturation Peptidase Activity Plasma Membrane Repair Regulation Of Response To Tumor Cell Negative Regulation Of Translation Cellular Response To Alkaloid Regulation Of Glycoprotein Biosynthetic Process Hydrolase Activity Cytoplasm Protein Sequestering Activity Leukocyte Apoptotic Process Neuron Recognition Glutamatergic Synapse Negative Regulation Of Translational Initiation Postsynapse Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Ceramide Biosynthetic Process Identical Protein Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Regulation Of Metabolic Process Proteolysis Cysteine-type Endopeptidase Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Synapse Organization Striated Muscle Cell Differentiation Response To External Biotic Stimulus Phospholipase A2 Activator Activity Cytolytic Granule Lumen Leukocyte Mediated Cytotoxicity Synaptic Target Recognition Endoribonuclease Activity, Cleaving MiRNA-paired MRNA Negative Regulation Of G Protein-coupled Receptor Internalization	DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Response To Radiation Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Regulation Of Programmed Cell Death DNA-dependent Protein Kinase Complex Apoptotic Process Regulation Of Apoptotic Process Response To Anesthetic Response To Ionizing Radiation Cellular Response To Stress Protein Processing Protein Maturation Response To Cobalt Ion Telomere Maintenance Pyroptotic Inflammatory Response Fibroblast Apoptotic Process Protein-DNA Complex Neuron Apoptotic Process Granzyme-mediated Programmed Cell Death Signaling Pathway Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Response To Gamma Radiation Protein-containing Complex Telomere Organization Regulation Of Neuron Apoptotic Process Death Receptor Binding Double-strand Break Repair Via Nonhomologous End Joining Structural Constituent Of Nuclear Lamina Response To Stress Protein Poly-ADP-ribosylation Cysteine-type Endopeptidase Activity Response To UV Positive Regulation Of Neuron Apoptotic Process Enzyme Activator Activity Macromolecule Metabolic Process DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Chromosome, Telomeric Region Execution Phase Of Apoptosis Response To Light Stimulus Regulation Of Immune Response Apoptotic Signaling Pathway Response To Metal Ion Immune System Process Response To X-ray Regulation Of Immune System Process
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