DFFA and GZMM

Number of citations of the paper that reports this interaction (PMID 16818775)
9

Data Source:
BioGRID (enzymatic study)

		DFFA	GZMM
Gene Name		DNA fragmentation factor, 45kDa, alpha polypeptide	granzyme M (lymphocyte met-ase 1)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Lipid Particle Cytosol	Extracellular Region Membrane
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Apoptotic DNA Fragmentation	Proteolysis Apoptotic Process Cytolysis Innate Immune Response
Pathways		Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase	Alternative complement activation Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP3 CASP7 CIDEB DFFB EWSR1 GZMB GZMM NECAB2 STRN4 YWHAG YWHAZ	5 interactors: DFFA EZR NPM1 PARP1 TUBA1B
Entrez ID		1676	3004
HPRD ID		03531	02633
Ensembl ID			ENSG00000197540
Uniprot IDs		O00273	P51124
PDB IDs		1IBX 1IYR 1KOY	1LZP 2ZGC 2ZGH 2ZGJ 2ZKS
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Protein Processing Activation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Zymogen Activation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Positive Regulation Of Organelle Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic DNA Fragmentation Positive Regulation Of Peptidase Activity Intracellular Signal Transduction Cytolysis Apoptotic Nuclear Changes Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Proteolysis Regulation Of Organelle Organization Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cellular Component Organization DNA Catabolic Process, Endonucleolytic Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Catabolic Process Golgi Reassembly Apoptotic Chromosome Condensation Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization	Negative Regulation Of Apoptotic DNA Fragmentation Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Growth Rate Protein Poly-ADP-ribosylation Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity DNA Metabolic Process Membrane To Membrane Docking Cytoskeleton Organization Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Organelle Organization Regulation Of Apoptotic DNA Fragmentation DNA Damage Response, Detection Of DNA Damage Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Transcription Regulatory Region DNA Binding Protein Autoprocessing Cytoskeletal Anchoring At Plasma Membrane Regulation Of Centriole Replication Positive Regulation Of Gene Expression Positive Regulation Of SMAD Protein Import Into Nucleus Microvillus Assembly Microvillus Organization Negative Regulation Of Centrosome Duplication Microtubule Cytoskeleton Organization Regulation Of SMAD Protein Import Into Nucleus T Cell Apoptotic Process Filopodium Assembly Apoptotic DNA Fragmentation Macrophage Differentiation Cellular Response To Organic Substance Cellular Component Assembly Cellular Response To Superoxide Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Execution Phase Of Apoptosis CENP-A Containing Nucleosome Assembly Response To Superoxide Protein ADP-ribosylation Response To Oxygen Radical Establishment Of Endothelial Barrier Negative Regulation Of Cellular Metabolic Process DNA Repair Ribosome Assembly Apoptotic Nuclear Changes Cellular Macromolecular Complex Assembly Histone Exchange Signal Transduction Involved In Regulation Of Gene Expression
Tagcloud ?		cd40 cd71 dysplastic effector erythroid erythropoiesis etv6 fas glya gm hematopoiesis hemoglobin ineffective leukemic making megakaryocyte meps microrna mir9 mirna mirnas profiling progenitors robust runx1 sorted speculating sub ut
Tagcloud (Difference) ?		cd40 cd71 dysplastic effector erythroid erythropoiesis etv6 fas glya gm hematopoiesis hemoglobin ineffective leukemic making megakaryocyte meps microrna mir9 mirna mirnas profiling progenitors robust runx1 sorted speculating sub ut
Tagcloud (Intersection) ?