CTTNBP2 and CTTN

Number of citations: 0 (PubMedID 9813110)
Data Source: HPRD (in vitro)

		CTTNBP2	CTTN
Name		cortactin binding protein 2	cortactin
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cell Cortex Synaptic Vesicle Cell Projection Dendritic Spine Synapse FAR/SIN/STRIPAK Complex Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding
	Biological Process	Regulation Of Synapse Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	RHO GTPases activate PAKs Clathrin-mediated endocytosis
GWAS		Brain morphology (MOSTest) ( 32665545 ) General factor of neuroticism ( 30867560 ) Glaucoma ( 30054594 31959993 ) Glaucoma (primary open-angle) ( 33627673 29891935 ) Idiopathic osteonecrosis of the femoral head ( 28000841 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Myocardial infarction ( 33532862 ) Positive urgency ( 30718321 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Smoking initiation ( 30617275 33082346 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (current vs never) ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Sociability score ( 34054130 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 30108155 ) Type 2 diabetes ( 30297969 30054458 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Worry too long after an embarrassing experience ( 34054130 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: APPL1 BMAL2 CTTN FAM86C1P HSF2BP INCA1 KRT14 MAGEA11 MEI4 PKNOX2	58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3
Entrez ID		83992	2017
HPRD ID		09890	01268
Ensembl ID		ENSG00000077063	ENSG00000085733
Uniprot IDs		Q20BG9 Q8WZ74	Q14247 Q53HG7
PDB IDs		Not available	1X69 2D1X
GO Terms Enriched among Interactors		None	SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization