GNG4 and TFIP11

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GNG4	TFIP11
Gene Name		guanine nucleotide binding protein (G protein), gamma 4	tuftelin interacting protein 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Spliceosomal Complex Cytoplasm Nuclear Speck U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Signal Transducer Activity Protein Binding	DNA Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Cell Growth Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated RNA Processing Biomineral Tissue Development
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS		Aging traits ( 17903295)
Protein-Protein Interactions		8 interactors: GNB1 GNB2 GNB3 GNB4 GNB5 RAF1 TFIP11 USHBP1	102 interactors: ABI2 ADCK3 AIMP2 ALS2CR11 ANKRD11 ARMCX1 ARNT2 ATP5O BMF C1orf109 C6orf165 CARD9 CCDC116 CCDC121 CCDC146 CCDC151 CCDC42 CCDC68 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CENPU CEP57 CEP57L1 COX5B DGCR6 DISC1 EIF3A FAM13C FAM156A FAM161A FAM50B GCC1 GEM GNG4 GOLGA1 GPS2 HAUS1 HMG20B HOOK1 IKBIP IMP3 KANSL1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5L LENG1 LIN37 LINC00238 LMO1 LMO4 LSP1P3 METTL17 MTFR2 NDC80 NDE1 NDN NFU1 OIP5 PBX4 PDE4DIP POLL PPP1R18 PRPF31 RCOR3 RHNO1 RRP7A S100P SAP30BP SFR1 SH2D4A SH3GLB1 SMARCE1 SNRPB SNW1 SNX20 SSX2IP STRN TCAF1 TFPT THAP7 THAP8 TNNT1 TRAF3IP3 TRAPPC4 TSHZ3 TSPYL4 TUFT1 TXLNA VPS37C ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZSCAN12
Entrez ID		2786	24144
HPRD ID		11978	11628
Ensembl ID		ENSG00000168243	ENSG00000100109
Uniprot IDs		B1APZ0 P50150	Q9UBB9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Energy Reserve Metabolic Process Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Energy Derivation By Oxidation Of Organic Compounds Response To Organonitrogen Compound Response To Hormone Generation Of Precursor Metabolites And Energy Synaptic Transmission Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Cellular Response To Organic Substance Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Phototransduction, Visible Light Response To Organic Substance Detection Of Visible Light Death-inducing Signaling Complex Assembly Spliceosomal Complex Disassembly Cellular Response To Light Stimulus Phototransduction Detection Of Light Stimulus Oxidation-reduction Process Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Radiation Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell Communication Platelet Activation Negative Regulation Of Voltage-gated Calcium Channel Activity Ras Protein Signal Transduction Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Cellular Response To Stimulus Small Molecule Metabolic Process Response To Abiotic Stimulus Response To Hypoxia Cellular Response To Prostaglandin E Stimulus Response To Light Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Prostaglandin Stimulus	Organelle Organization Cell Cycle Mitotic Cell Cycle Cellular Component Assembly Mitotic Cell Cycle Process Cell Cycle Process Cellular Macromolecular Complex Assembly G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Cell Division Mitotic Nuclear Division Nucleosome Organization Chromatin Assembly Or Disassembly Mitotic Cell Cycle Phase Transition Cytoskeleton Organization Cell Cycle Phase Transition Centrosome Organization Microtubule Anchoring Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Organizing Center Organization Chromosome Organization Gene Expression Nucleosome Assembly Microtubule-based Process Maintenance Of Protein Location In Cell Organelle Assembly Maintenance Of Protein Location Chromatin Assembly Maintenance Of Location In Cell Transcription, DNA-templated ATP-dependent Chromatin Remodeling RNA Metabolic Process Anatomical Structure Development Cellular Localization RNA Biosynthetic Process Positive Regulation Of Protein Oligomerization Protein-DNA Complex Assembly Chromatin Organization Ribonucleoprotein Complex Assembly Cellular Macromolecule Biosynthetic Process Recombinational Repair Nucleobase-containing Compound Metabolic Process Protein Targeting To Golgi Chromatin Remodeling Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Macromolecule Biosynthetic Process DNA Packaging CENP-A Containing Nucleosome Assembly Kidney Smooth Muscle Cell Differentiation
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