GNG4 and GNB5

Number of citations of the paper that reports this interaction (PMID 8636150)
15

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GNG4	GNB5
Gene Name		guanine nucleotide binding protein (G protein), gamma 4	guanine nucleotide binding protein (G protein), beta 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Nucleus Plasma Membrane
	Molecular Function	Signal Transducer Activity Protein Binding	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Cell Growth Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Aging traits ( 17903295)
Protein-Protein Interactions		8 interactors: GNB1 GNB2 GNB3 GNB4 GNB5 RAF1 TFIP11 USHBP1	26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		2786	10681
HPRD ID		11978	09191
Ensembl ID		ENSG00000168243	ENSG00000069966
Uniprot IDs		B1APZ0 P50150	B3KWS4 O14775
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Energy Reserve Metabolic Process Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Energy Derivation By Oxidation Of Organic Compounds Response To Organonitrogen Compound Response To Hormone Generation Of Precursor Metabolites And Energy Synaptic Transmission Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Cellular Response To Organic Substance Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Phototransduction, Visible Light Response To Organic Substance Detection Of Visible Light Death-inducing Signaling Complex Assembly Spliceosomal Complex Disassembly Cellular Response To Light Stimulus Phototransduction Detection Of Light Stimulus Oxidation-reduction Process Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Radiation Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell Communication Platelet Activation Negative Regulation Of Voltage-gated Calcium Channel Activity Ras Protein Signal Transduction Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Cellular Response To Stimulus Small Molecule Metabolic Process Response To Abiotic Stimulus Response To Hypoxia Cellular Response To Prostaglandin E Stimulus Response To Light Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Prostaglandin Stimulus	Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway
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