RBM4B and KLF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBM4B	KLF1
Description		RNA binding motif protein 4B	KLF transcription factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck Protein-containing Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of Translation Circadian Rhythm RNA Splicing Positive Regulation Of Gene Expression Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Erythrocyte Differentiation Protein Destabilization Positive Regulation Of DNA-templated Transcription Maternal Process Involved In Female Pregnancy Cellular Response To Endothelin
Pathways
Drugs
Diseases			Congenital dyserythropoietic anemias (CDAs)
GWAS		Bipolar disorder ( 21926972)	Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		22 interacting genes: APC APP ATN1 DZIP3 HNRNPM HNRNPUL1 KLF1 MIR21 MIR214 MIR34B MIR9-2 MIRLET7B MIRLET7C MIRLET7D MIRLET7G MIRLET7I MRPS9 NFKBID POLR2M SMYD1 SNRPA TSGA10IP	32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C
Entrez ID		83759	10661
HPRD ID		15230	07197
Ensembl ID		ENSG00000173914	ENSG00000105610
Uniprot IDs		E9PLB0 Q9BQ04	Q13351
PDB IDs		2DGT	2L2I 2MBH 2N23
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Gene Expression Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Catabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of MRNA Stability Regulation Of Cardiac Muscle Hypertrophy Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of RNA Stability Regulation Of Connective Tissue Replacement Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Signal Transduction Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Tissue Remodeling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Gene Expression Alternative MRNA Splicing, Via Spliceosome Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of T-helper Cell Differentiation	NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Regulation Of Nucleotide-excision Repair SWI/SNF Complex Brahma Complex Regulation Of Double-strand Break Repair RSC-type Complex Regulation Of G0 To G1 Transition Regulation Of Chromosome Segregation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance BBAF Complex Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Positive Regulation Of T Cell Differentiation Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Regulation Of Myoblast Differentiation Regulation Of Cellular Response To Stress Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Sister Chromatid Segregation Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Chromatin Positive Regulation Of Leukocyte Differentiation Regulation Of RNA Metabolic Process Nucleosome Organization Regulation Of Lymphocyte Differentiation Nucleoplasm Protein-containing Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Cell Adhesion Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of T Cell Activation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition
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