ITCH and DVL2

Number of citations of the paper that reports this interaction (PMID 22826439)
9

Data Source:
BioGRID (enzymatic study)

		ITCH	DVL2
Gene Name		itchy E3 ubiquitin protein ligase	dishevelled segment polarity protein 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Ribonucleoprotein Complex Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association
	Biological Process	Regulation Of Cell Growth Positive Regulation Of T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Inflammatory Response Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOD1/2 Signaling Pathway Signaling by NOTCH1 Hedgehog 'on' state Signaling by NOTCH1 in Cancer Class I MHC mediated antigen processing & presentation FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Downregulation of ERBB4 signaling Signaling by NOTCH Signaling by ERBB4 Activated NOTCH1 Transmits Signal to the Nucleus RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by Hedgehog Degradation of GLI1 by the proteasome Adaptive Immune System	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		80 interactors: ARID1A ARRB2 ARRDC1 ARRDC3 ATN1 BECN1 CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L DVL2 ERBB4 EWSR1 FYN GNAI2 HNRNPL HNRNPUL1 JUN LAPTM5 LATS1 LITAF MAP2K4 MAPK8 MLANA N4BP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SNX9 SPG20 STAM2 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 URI1 WBP2	61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263
Entrez ID		83737	1856
HPRD ID		07565	03690
Ensembl ID		ENSG00000078747	ENSG00000004975
Uniprot IDs		Q96J02	I3L2N2 O14641
PDB IDs		2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG	2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Protein Polyubiquitination Regulation Of Signaling Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nucleosome Disassembly TRIF-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Protein Catabolic Process Regulation Of Cellular Component Organization DNA-templated Transcription, Initiation Cell Death Death MRNA Splicing, Via Spliceosome	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta
Tagcloud ?		ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Difference) ?		ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Intersection) ?