HIST1H4A and BRD2

Number of citations of the paper that reports this interaction (PMID 19766566)
105

Data Source:
BioGRID (unspecified method, fluorescent resonance energy transfer)

		HIST1H4A	BRD2
Gene Name		histone cluster 1, H4a	bromodomain containing 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Chromatin Modification
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		73 interactors: ANP32A BAZ1B BAZ2A BLOC1S1 BRD2 CALCOCO1 CBX3 CDK1 CDK2 COPS2 CREBBP CTDP1 DYRK1A EID1 ELP3 EP300 ERCC6 GATAD2A GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC8 HIRIP3 HIST1H3A HIST2H2AC HIST2H2BE HJURP KAT2A KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2A L3MBTL2 MSL2 MSL3 NASP NCOR1 NCOR2 NPM1 NR1H4 PAK1 PARP1 PARP10 PBRM1 PELP1 PHF20 PHF8 PRMT1 PRMT5 PRMT7 PRMT8 PTMA RCC1 SETD7 SIRT7 SSRP1 SUV420H1 SUV420H2 TAF1 TAF1A TAF1B TBL1X THAP7 TP53BP1 UBC UBE2I UCHL5 YY1	7 interactors: E2F1 E2F2 HIST1H4A HIST2H2BE HIST3H2BB HIST4H4 TBP
Entrez ID		8359	6046
HPRD ID		04157	03326
Ensembl ID		ENSG00000196176	ENSG00000204256
Uniprot IDs		B2R4R0 P62805	P25440 Q63HQ9 Q658Y7
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA	1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Regulation Of Metabolic Process Peptidyl-lysine Acetylation Peptidyl-amino Acid Modification Protein Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Histone Acetylation Negative Regulation Of RNA Biosynthetic Process Internal Peptidyl-lysine Acetylation Cellular Protein Modification Process Internal Protein Amino Acid Acetylation Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Histone H4 Acetylation Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Chromatin Remodeling Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter	Chromatin Silencing At RDNA Chromatin Silencing Histone H4-K20 Demethylation Lens Fiber Cell Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly DNA Methylation On Cytosine Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Regulation Of Gene Expression, Epigenetic CENP-A Containing Nucleosome Assembly Chromatin Organization Mitotic Cell Cycle Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation DNA Replication-independent Nucleosome Assembly Histone Demethylation Protein Demethylation DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centromere Complex Assembly Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Demethylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP-dependent Chromatin Remodeling Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Signal Transduction By P53 Class Mediator Cellular Macromolecular Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Gene Expression Regulation Of Myeloid Cell Differentiation Chromatin Remodeling
Tagcloud ?			abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft
Tagcloud (Difference) ?			abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft
Tagcloud (Intersection) ?