BRD2 and E2F1

Number of citations of the paper that reports this interaction (PMID 10965846)
49

Data Source:
HPRD (in vivo)

		BRD2	E2F1
Gene Name		bromodomain containing 2	E2F transcription factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Rb-E2F Complex
	Molecular Function	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Chromatin Modification	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Notch Signaling Pathway Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Anoikis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Cellular Response To Fatty Acid Cellular Response To Hypoxia Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Cellular Senescence Activation of BH3-only proteins Oncogene Induced Senescence Assembly of the pre-replicative complex Pre-NOTCH Transcription and Translation G2 Phase G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase M/G1 Transition Regulation of DNA replication G0 and Early G1 CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: E2F1 E2F2 HIST1H4A HIST2H2BE HIST3H2BB HIST4H4 TBP	70 interactors: ARID3A ATAD2 ATM ATR BRCA1 BRD2 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 DDB2 E2F6 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NDNL2 NFKB1 NPDC1 NRIP1 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RNF144A SERTAD2 SETD7 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP VHL YWHAQ
Entrez ID		6046	1869
HPRD ID		03326	01806
Ensembl ID		ENSG00000204256	ENSG00000101412
Uniprot IDs		P25440 Q63HQ9 Q658Y7	Q01094 Q9BSD8
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH	1H24 1O9K 2AZE
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Chromatin Silencing Histone H4-K20 Demethylation Lens Fiber Cell Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly DNA Methylation On Cytosine Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Regulation Of Gene Expression, Epigenetic CENP-A Containing Nucleosome Assembly Chromatin Organization Mitotic Cell Cycle Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation DNA Replication-independent Nucleosome Assembly Histone Demethylation Protein Demethylation DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centromere Complex Assembly Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Demethylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP-dependent Chromatin Remodeling Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Signal Transduction By P53 Class Mediator Cellular Macromolecular Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Gene Expression Regulation Of Myeloid Cell Differentiation Chromatin Remodeling	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Process Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process DNA Repair Cellular Response To Stress DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Difference) ?		abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft	box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike
Tagcloud (Intersection) ?