BRD2 and HIST3H2BB

Number of citations of the paper that reports this interaction (PMID 14731392)
83

Data Source:
HPRD (in vivo, in vitro)

		BRD2	HIST3H2BB
Gene Name		bromodomain containing 2	histone cluster 3, H2bb
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleosome Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Chromatin Modification	Chromatin Organization
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: E2F1 E2F2 HIST1H4A HIST2H2BE HIST3H2BB HIST4H4 TBP	5 interactors: BRD2 CBX5 CDKN2A RPS6KA5 USP7
Entrez ID		6046	128312
HPRD ID		03326	13661
Ensembl ID		ENSG00000204256	ENSG00000196890
Uniprot IDs		P25440 Q63HQ9 Q658Y7	Q8N257
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Chromatin Silencing Histone H4-K20 Demethylation Lens Fiber Cell Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly DNA Methylation On Cytosine Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Regulation Of Gene Expression, Epigenetic CENP-A Containing Nucleosome Assembly Chromatin Organization Mitotic Cell Cycle Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation DNA Replication-independent Nucleosome Assembly Histone Demethylation Protein Demethylation DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centromere Complex Assembly Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Demethylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP-dependent Chromatin Remodeling Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Signal Transduction By P53 Class Mediator Cellular Macromolecular Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Gene Expression Regulation Of Myeloid Cell Differentiation Chromatin Remodeling	Chromatin Modification Chromatin Organization Chromosome Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Transcription, DNA-templated Histone H2A-S1 Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Assembly Regulation Of Gene Expression Chromatin Assembly Or Disassembly Regulation Of Nitrogen Compound Metabolic Process DNA Packaging Senescence-associated Heterochromatin Focus Assembly Histone H3-S10 Phosphorylation Positive Regulation Of Cellular Senescence Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Conformation Change Negative Regulation Of Immature T Cell Proliferation In Thymus Organelle Organization Positive Regulation Of Macrophage Apoptotic Process Maintenance Of DNA Methylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic DNA Fragmentation Histone H3-S28 Phosphorylation Positive Regulation Of Cell Aging Response To Stress Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Cellular Response To Stress Heterochromatin Assembly Histone Modification Positive Regulation Of Protein Sumoylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Smooth Muscle Cell Apoptotic Process Heterochromatin Organization Regulation Of Metabolic Process Regulation Of Macrophage Apoptotic Process Replicative Senescence Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Interleukin-1-mediated Signaling Pathway
Tagcloud ?		abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft
Tagcloud (Difference) ?		abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft
Tagcloud (Intersection) ?