BRD2 and HIST2H2BE

Number of citations of the paper that reports this interaction (PMID 14731392)
83

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BRD2	HIST2H2BE
Gene Name		bromodomain containing 2	histone cluster 2, H2be
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding	DNA Binding Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Chromatin Modification	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: E2F1 E2F2 HIST1H4A HIST2H2BE HIST3H2BB HIST4H4 TBP	74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1
Entrez ID		6046	8349
HPRD ID		03326	03494
Ensembl ID		ENSG00000204256	ENSG00000184678
Uniprot IDs		P25440 Q63HQ9 Q658Y7	Q16778
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Chromatin Silencing Histone H4-K20 Demethylation Lens Fiber Cell Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly DNA Methylation On Cytosine Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Regulation Of Gene Expression, Epigenetic CENP-A Containing Nucleosome Assembly Chromatin Organization Mitotic Cell Cycle Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation DNA Replication-independent Nucleosome Assembly Histone Demethylation Protein Demethylation DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centromere Complex Assembly Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Demethylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP-dependent Chromatin Remodeling Telomere Maintenance Negative Regulation Of Myeloid Cell Differentiation DNA Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Signal Transduction By P53 Class Mediator Cellular Macromolecular Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Gene Expression Regulation Of Myeloid Cell Differentiation Chromatin Remodeling	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation
Tagcloud ?		abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft	5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis
Tagcloud (Difference) ?		abc bet brd4 bromodomain btk constitutive cytoplasm diffuse dlbcl extraterminal favorably ibrutinib ikappab ikk jq1 killing maintaining mechanistic modulators oncogenic platform programs screen sustained synergized synergy throughput unexpected xenograft	5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis
Tagcloud (Intersection) ?