FZD7 and NCS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FZD7	NCS1
Description		frizzled class receptor 7	neuronal calcium sensor 1
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Frizzled Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Stem Cell Population Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Non-canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal To Epithelial Transition Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid Negative Regulation Of Cardiac Muscle Cell Differentiation	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport
Pathways		Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258) Total body bone mineral density ( 29304378)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		30 interacting genes: ADCY1 AIG1 AQP9 BCL2L13 CCDC88C CLN8 CLPTM1 DLG1 DLG2 DLG4 DVL1 FFAR2 GNAS HPCAL1 LEUTX MAGI3 MGST1 NCALD NCS1 PDAP1 PRNP PSME3IP1 SGTA SGTB SLC30A4 SLC35B1 TMEM237 UBQLN1 UBQLN2 UBQLN4	26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		8324	23413
HPRD ID		04560	04500
Ensembl ID		ENSG00000155760	ENSG00000107130
Uniprot IDs		O75084	P62166
PDB IDs		4Z33 5T44 5URV 5WBS 6NE2 6NE4 6O3A 6O3B 8QEO 8YY8 9EPO 9EW2	1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM
Enriched GO Terms of Interacting Partners?		Postsynaptic Density GMP Kinase Activity Ionotropic Glutamate Receptor Binding Regulation Of Proteolysis GDP Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Receptor Clustering TRC Complex Positive Regulation Of ERAD Pathway Membrane Ribonucleoside Diphosphate Metabolic Process Regulation Of ERAD Pathway Nucleoside Diphosphate Metabolic Process GMP Metabolic Process Dendritic Spine Organization Kinase Binding Frizzled Binding Postsynaptic Density Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Neuron Projection Organization D1 Dopamine Receptor Binding Postsynapse Organization Plasma Membrane Positive Regulation Of Neuron Projection Arborization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Proteolysis Social Behavior Purine Ribonucleotide Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Synapse Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribonucleotide Metabolic Process Establishment Or Maintenance Of Cell Polarity Juxtaparanode Region Of Axon Cytoplasmic Microtubule Organization Ribose Phosphate Metabolic Process Cognition Cellular Response To Metal Ion Immunological Synapse Formation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cellular Response To Potassium Ion Response To Metal Ion Nucleoside Monophosphate Metabolic Process	Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
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