NCS1 and KCND2

Number of citations of the paper that reports this interaction (PMID 11606724)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NCS1	KCND2
Gene Name		neuronal calcium sensor 1	potassium channel, voltage gated Shal related subfamily D, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Axon Dendrite Dense Core Granule Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Dendritic Spine
	Molecular Function	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport	Action Potential Synaptic Transmission Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways			Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)	Alcohol and nictotine co-dependence ( 22488850) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		9 interactors: ADRBK1 DRD2 DRD3 DRD5 DTX2 IL1RAPL1 KCND2 NBL1 PI4KB	8 interactors: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1
Entrez ID		23413	3751
HPRD ID		04500	09254
Ensembl ID		ENSG00000107130	ENSG00000184408
Uniprot IDs		P62166	A4D0V9 Q75LS7 Q9NZV8
PDB IDs		1G8I 2LCP
Enriched GO Terms of Interacting Partners?		Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Dopamine Receptor Signaling Pathway Response To Amphetamine Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Receptor Internalization Negative Regulation Of Blood Pressure Response To Cocaine Response To Amine Regulation Of Adenylate Cyclase Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Cyclase Activity Neuron-neuron Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Receptor Metabolic Process Associative Learning Blood Circulation Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of CAMP Biosynthetic Process Response To Ammonium Ion Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Positive Regulation Of Renal Sodium Excretion Response To Histamine G-protein Coupled Receptor Internalization Arachidonic Acid Secretion Behavioral Response To Cocaine Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Ion Transmembrane Transport Regulation Of Neurotransmitter Uptake Prepulse Inhibition Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Learning Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Synaptic Transmission, Dopaminergic G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Alkaloid Negative Regulation Of Secretion By Cell Regulation Of Renal Sodium Excretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Dopamine Secretion Negative Regulation Of Lyase Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Excretion	Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Detection Of Calcium Ion Potassium Ion Transmembrane Transport Potassium Ion Transport Metal Ion Transport Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Response To Calcium Ion Synaptic Transmission Regulation Of Ion Transmembrane Transporter Activity Clustering Of Voltage-gated Potassium Channels Regulation Of Transmembrane Transporter Activity Monovalent Inorganic Cation Transport Transmembrane Transport Regulation Of Behavior Ion Transport Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Cell-cell Signaling Negative Regulation Of Receptor Internalization Positive Regulation Of Action Potential Locomotory Exploration Behavior Regulation Of Membrane Potential Potassium Ion Export Dendritic Spine Morphogenesis Neuronal Ion Channel Clustering Maintenance Of Cell Polarity Synaptic Vesicle Maturation Membrane Repolarization Vocalization Behavior Response To Metal Ion Induction Of Positive Chemotaxis Dendritic Spine Development Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Detection Of Chemical Stimulus Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization
Tagcloud ?		17a 17f 1bb augment bet bipolarization car cars cd161 cd28 cd3zeta costimulator exception expand generates hematologic icos il1r nonlymphoid notable note persist persistence redirected redirection rorc th1 th17 transferred	channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnj3 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Difference) ?		17a 17f 1bb augment bet bipolarization car cars cd161 cd28 cd3zeta costimulator exception expand generates hematologic icos il1r nonlymphoid notable note persist persistence redirected redirection rorc th1 th17 transferred	channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnj3 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Intersection) ?