NCS1 and KCND2

Number of citations: 42 (PubMedID 11606724)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		NCS1	KCND2
Name		neuronal calcium sensor 1	potassium voltage-gated channel subfamily D member 2
Structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Dendrite Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Plasma Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Kv4.2-KChIP2 Channel Complex Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport	Action Potential Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Chemical Synaptic Transmission Regulation Of Heart Contraction Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Membrane Repolarization
Pathways		None	Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Enflurane Disopyramide Imipramine Promethazine Miconazole Dalfampridine
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Tuberculosis ( 30713548 )	Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Alcohol and nicotine co-dependence ( 22488850 ) Heel bone mineral density ( 30598549 ) Immune reponse to smallpox (secreted IL-12p40) ( 22610502 ) Maximum stenosis ( 32469969 ) Mean degree of stenosis ( 32469969 )
Novel Interactors		1 novel interactors: EXOSC2	1 novel interactors: MET
Interacting Genes		26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	8 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1
Entrez ID		23413	3751
HPRD ID		04500	09254
Ensembl ID		ENSG00000107130	ENSG00000184408
Uniprot IDs		P62166	A4D0V9 Q9NZV8
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM	7E7Z 7E83 7E84 7E87 7E8B 7E8E 7E8H 7F0J 7F3F 7UK5 7UKC 7UKD 7UKE 7UKF 7UKG 7UKH
GO Terms Enriched among Interactors		Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Voltage-gated Potassium Channel Complex Potassium Channel Regulator Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Complex Regulation Of Transport Transmembrane Transporter Binding Regulation Of Membrane Potential Potassium Ion Transmembrane Transport Dendrite Potassium Ion Transport Membrane Repolarization Metal Ion Transport Protein Localization To Cell Periphery Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Binding Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Protein Localization To Membrane P2Y1 Nucleotide Receptor Binding Hepatocyte Growth Factor Receptor Activity Trans-synaptic Signaling Synaptic Signaling Monoatomic Ion Transport Synapse Protein Phosphatase Binding Kv4.2-KChIP2 Channel Complex Kv4.3-KChIP1 Channel Complex Regulation Of Signal Transduction Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation Transmembrane Transport Localization Within Membrane Positive Regulation Of Potassium Ion Export Across Plasma Membrane Clustering Of Voltage-gated Potassium Channels A-type (transient Outward) Potassium Channel Activity AMPA Glutamate Receptor Clustering Regulation Of System Process Neuroligin Family Protein Binding Positive Regulation Of Chemotaxis