NCS1 and PI4KB

Number of citations: 0 (PubMedID 11526106)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		NCS1	PI4KB
Name		neuronal calcium sensor 1	phosphatidylinositol 4-kinase beta
Structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding	Nucleotide Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity 14-3-3 Protein Binding
	Biological Process	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Lysosome Organization Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Inner Ear Development
Pathways		None	Synthesis of PIPs at the Golgi membrane
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Fostamatinib
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Tuberculosis ( 30713548 )	Body mass index ( 26426971 ) Gut microbiota (functional units) ( 27694959 )
Novel Interactors		1 novel interactors: EXOSC2	None recorded
Interacting Genes		26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	5 interacting genes: MYCBP2 NCS1 YWHAB YWHAG YWHAQ
Entrez ID		23413	5298
HPRD ID		04500	11805
Ensembl ID		ENSG00000107130	ENSG00000143393
Uniprot IDs		P62166	A0A0B4J1S8 Q9UBF8
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM	2N73 4D0L 4D0M 4WAE 4WAG 5C46 5C4G 5EUQ 5FBL 5FBQ 5FBR 5FBV 5FBW 5LX2 5NAS 6GL3 8Q6F 8Q6G 8Q6H 8VOF
GO Terms Enriched among Interactors		Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Focal Adhesion Identical Protein Binding Protein Kinase C Inhibitor Activity