FZD7 and CCDC88C

Number of citations of the paper that reports this interaction (PubMedID 26126266)
145

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FZD7	CCDC88C
Description		frizzled class receptor 7	coiled-coil and HOOK domain protein 88C
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Extracellular Region Cytoplasm Centrosome Cell Junction Apical Junction Complex Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Frizzled Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Frizzled Binding Protein Binding Microtubule Binding PDZ Domain Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Stem Cell Population Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Non-canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal To Epithelial Transition Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid Negative Regulation Of Cardiac Muscle Cell Differentiation	Microtubule Bundle Formation Cilium Movement Apical Constriction Negative Regulation Of Microtubule Depolymerization Signal Transduction Small GTPase-mediated Signal Transduction Wnt Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Protein Destabilization Non-canonical Wnt Signaling Pathway Cilium Organization Positive Regulation Of JNK Cascade Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Mucociliary Clearance Respiratory Basal Cell Differentiation
Pathways		Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258) Total body bone mineral density ( 29304378)	Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Daytime sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		30 interacting genes: ADCY1 AIG1 AQP9 BCL2L13 CCDC88C CLN8 CLPTM1 DLG1 DLG2 DLG4 DVL1 FFAR2 GNAS HPCAL1 LEUTX MAGI3 MGST1 NCALD NCS1 PDAP1 PRNP PSME3IP1 SGTA SGTB SLC30A4 SLC35B1 TMEM237 UBQLN1 UBQLN2 UBQLN4	9 interacting genes: APP DVL1 FBXO7 FZD6 FZD7 GNAI3 ITSN2 MAPK8 MPDZ
Entrez ID		8324	440193
HPRD ID		04560	19136
Ensembl ID		ENSG00000155760	ENSG00000015133
Uniprot IDs		O75084	B4DZB8 Q9P219
PDB IDs		4Z33 5T44 5URV 5WBS 6NE2 6NE4 6O3A 6O3B 8QEO 8YY8 9EPO 9EW2
Enriched GO Terms of Interacting Partners?		Postsynaptic Density GMP Kinase Activity Ionotropic Glutamate Receptor Binding Regulation Of Proteolysis GDP Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Receptor Clustering TRC Complex Positive Regulation Of ERAD Pathway Membrane Ribonucleoside Diphosphate Metabolic Process Regulation Of ERAD Pathway Nucleoside Diphosphate Metabolic Process GMP Metabolic Process Dendritic Spine Organization Kinase Binding Frizzled Binding Postsynaptic Density Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Neuron Projection Organization D1 Dopamine Receptor Binding Postsynapse Organization Plasma Membrane Positive Regulation Of Neuron Projection Arborization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Proteolysis Social Behavior Purine Ribonucleotide Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Synapse Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribonucleotide Metabolic Process Establishment Or Maintenance Of Cell Polarity Juxtaparanode Region Of Axon Cytoplasmic Microtubule Organization Ribose Phosphate Metabolic Process Cognition Cellular Response To Metal Ion Immunological Synapse Formation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cellular Response To Potassium Ion Response To Metal Ion Nucleoside Monophosphate Metabolic Process	Frizzled Binding Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Catabolic Process Canonical Wnt Signaling Pathway Collateral Sprouting Wnt Receptor Activity Neuronal Dense Core Vesicle Protein Serine/threonine Kinase Binding Apicolateral Plasma Membrane Wnt-protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Macroautophagy Neuron Projection Organization Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Activation Modulation Of Excitatory Postsynaptic Potential Wnt Signaling Pathway JUN Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Neuron Projection Regulation Of Purine Nucleotide Metabolic Process G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization To Presynapse Positive Regulation Of Cardiolipin Metabolic Process Clathrin-dependent Synaptic Vesicle Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import
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