NCS1 and RNASEH1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NCS1	RNASEH1
Name		neuronal calcium sensor 1	ribonuclease H1
Structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding	Magnesium Ion Binding Nucleic Acid Binding RNA Binding Nuclease Activity Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport	RNA Catabolic Process DNA Replication, Removal Of RNA Primer
Pathways		None	Strand-asynchronous mitochondrial DNA replication
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Tuberculosis ( 30713548 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: EXOSC2	None recorded
Interacting Genes		26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	9 interacting genes: ASPH CRYAA EMD FAM3C NCS1 NRM TM9SF1 TMEM11 TRIM63
Entrez ID		23413	246243
HPRD ID		04500	04989
Ensembl ID		ENSG00000107130	ENSG00000171865
Uniprot IDs		P62166	B3KUD4 E5KN15 O60930
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM	2QK9 2QKB 2QKK 3BSU 6VRD 8SWB 8SWC
GO Terms Enriched among Interactors		Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Cortical Endoplasmic Reticulum Muscle System Process Muscle Contraction Regulation Of Intracellular Transport Nuclear Inner Membrane TMEM240-body Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Intracellular Protein Transport Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation