NCS1 and SIGLEC9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NCS1	SIGLEC9
Description		neuronal calcium sensor 1	sialic acid binding Ig like lectin 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport	Cell Adhesion Cell Surface Receptor Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)	Body mass index ( 29273807) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252 32888494) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	4 interacting genes: BRICD5 LGALS3BP NCS1 SFTPC
Entrez ID		23413	27180
HPRD ID		04500	16133
Ensembl ID		ENSG00000107130	ENSG00000129450
Uniprot IDs		P62166	Q9Y336
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM
Enriched GO Terms of Interacting Partners?		Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Extracellular Space Lamellar Body Multivesicular Body Lumen Alveolar Lamellar Body Calcium Sensitive Guanylate Cyclase Activator Activity Mitochondrial Intermembrane Space Chaperone Complex
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