FZD7 and MAGI3

Number of citations of the paper that reports this interaction (PMID 15195140)
16

Data Source:
HPRD (two hybrid)

		FZD7	MAGI3
Gene Name		frizzled class receptor 7	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleus Plasma Membrane Tight Junction Membrane
	Molecular Function	G-protein Coupled Receptor Activity Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity	Guanylate Kinase Activity Frizzled Binding Protein Binding ATP Binding Protein Complex Scaffold
	Biological Process	Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Mesenchymal To Epithelial Transition Cellular Response To Retinoic Acid	Apoptotic Process Viral Process Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Nucleotide Phosphorylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Asymmetric localization of PCP proteins Signaling by Wnt Metabolic disorders of biological oxidation enzymes GPCR ligand binding PCP/CE pathway Class B/2 (Secretin family receptors) beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)	Bulimia nervosa ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: DLG1 DLG2 DLG4 MAGI3 UBQLN1 UBQLN4	14 interactors: ADRB1 BAI1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB TGFA TNK2 VANGL2
Entrez ID		8324	260425
HPRD ID		04560	11290
Ensembl ID		ENSG00000155760	ENSG00000081026
Uniprot IDs		O75084	Q5TCQ9
PDB IDs			3SOE
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Organophosphate Metabolic Process Protein Localization To Membrane Synaptic Transmission Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Cellular Protein Metabolic Process Membrane Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cell-cell Signaling T Cell Cytokine Production Small Molecule Metabolic Process Regulation Of Catalytic Activity Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Regulation Of Membrane Potential Negative Regulation Of Receptor Internalization Regulation Of Signal Transduction Peristalsis Cytokine Production Involved In Immune Response Immunological Synapse Formation Locomotory Exploration Behavior Phosphate-containing Compound Metabolic Process Dendritic Spine Morphogenesis Synaptic Vesicle Maturation Maintenance Of Cell Polarity Cellular Protein Localization Regulation Of Signaling Vocalization Behavior Amyloid Precursor Protein Metabolic Process Axon Guidance Regulation Of Phosphorus Metabolic Process Membrane Raft Organization Dendritic Spine Development Endothelial Cell Proliferation Regulation Of Ion Transmembrane Transport Positive Regulation Of Catalytic Activity Negative Regulation Of Receptor-mediated Endocytosis	Cell Morphogenesis Developmental Process Cell Morphogenesis Involved In Differentiation Neuron Differentiation Anatomical Structure Morphogenesis Cell Differentiation Generation Of Neurons System Development Neurogenesis Signaling Negative Regulation Of Cell Adhesion Cell Communication Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Multicellular Organismal Development Axonogenesis Anatomical Structure Development Neuron Development Axon Development Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Non-canonical Wnt Signaling Pathway Signal Transduction Nervous System Development Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Projection Organization Locomotion Blood Vessel Morphogenesis Negative Regulation Of Cell-substrate Adhesion Regulation Of Phosphorylation Regulation Of Cellular Component Organization Neuron Projection Development Positive Regulation Of Phosphorylation Cardiovascular System Development Positive Regulation Of Protein Modification Process Blood Vessel Development Response To Stimulus Vasculature Development Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Wnt Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Multicellular Organismal Response To Stress Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		199a 5p aberrant aberrantly biomarker called carcinogenesis elucidate fresh frizzled growing hcc hepatocarcinogenesis hepatocellular importantly indicates inversely jun mir mirnas perspective precise regulators restoration showing strengthened theoretical tumorigenesis wnt	aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam
Tagcloud (Difference) ?		199a 5p aberrant aberrantly biomarker called carcinogenesis elucidate fresh frizzled growing hcc hepatocarcinogenesis hepatocellular importantly indicates inversely jun mir mirnas perspective precise regulators restoration showing strengthened theoretical tumorigenesis wnt	aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam
Tagcloud (Intersection) ?