NCS1 and IL1RAPL1

Number of citations: 0 (PubMedID 12783849)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		NCS1	IL1RAPL1
Name		neuronal calcium sensor 1	interleukin 1 receptor accessory protein like 1
Structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Cell Surface Membrane Axon Dendrite Cell Projection Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding	Signaling Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Signal Transduction Regulation Of Neuron Projection Development Calcium Ion Transmembrane Transport	Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Exocytosis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Regulation Of Postsynapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		None	Receptor-type tyrosine-protein phosphatases Interleukin-38 signaling
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
Diseases		None	Non-syndromic X-linked mental retardation
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Tuberculosis ( 30713548 )	Cardiovascular risk factors (age interaction) ( 20838585 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Vitiligo ( 27723757 )
Novel Interactors		1 novel interactors: EXOSC2	1 novel interactors: POLA1
Interacting Genes		26 interacting genes: C1QTNF2 CDSN CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	2 interacting genes: ARHGAP22 NCS1
Entrez ID		23413	11141
HPRD ID		04500	02193
Ensembl ID		ENSG00000107130	ENSG00000169306
Uniprot IDs		P62166	Q9NZN1 X5DNQ7
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4 8AHY 8ALH 8ALM	1T3G 4M92 5WY8
GO Terms Enriched among Interactors		Dopamine Neurotransmitter Receptor Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Synaptic Transmission, Dopaminergic G Protein-coupled Dopamine Receptor Signaling Pathway Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Regulation Of Catecholamine Secretion Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Dopamine Binding Response To Cocaine Negative Regulation Of Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor-mediated Endocytosis Trans-synaptic Signaling Receptor Internalization Synaptic Signaling Prepulse Inhibition G Protein-coupled Receptor Internalization Regulation Of Amine Transport G Protein-coupled Receptor Activity Negative Regulation Of Cytosolic Calcium Ion Concentration Behavioral Response To Cocaine Response To Morphine Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Alkaloid TRNA Threonylcarbamoyladenosine Metabolic Process Associative Learning Regulation Of Neurotransmitter Uptake Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Arachidonate Secretion Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Non-motile Cilium Dopamine Metabolic Process Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Circadian Rhythm Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Cornification Chemical Synaptic Transmission Negative Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Mitotic DNA Replication Initiation Lagging Strand Elongation Alpha DNA Polymerase:primase Complex DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Calcium Sensitive Guanylate Cyclase Activator Activity DNA Replication, Synthesis Of Primer DNA Strand Elongation Involved In DNA Replication DNA Polymerase Activity DNA Replication Origin Binding DNA Strand Elongation DNA-directed DNA Polymerase Activity DNA Replication Initiation Voltage-gated Calcium Channel Activity