FZD7 and PDAP1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		FZD7	PDAP1
Description		frizzled class receptor 7	PDGFA associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Extracellular Region Cytosol Plasma Membrane Ficolin-1-rich Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Frizzled Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity	RNA Binding Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Stem Cell Population Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Non-canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal To Epithelial Transition Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid Negative Regulation Of Cardiac Muscle Cell Differentiation	Signal Transduction
Pathways		Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Neutrophil degranulation
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258) Total body bone mineral density ( 29304378)	Facial emotion recognition (sad faces) ( 28608620) Mean spheric corpuscular volume ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		30 interacting genes: ADCY1 AIG1 AQP9 BCL2L13 CCDC88C CLN8 CLPTM1 DLG1 DLG2 DLG4 DVL1 FFAR2 GNAS HPCAL1 LEUTX MAGI3 MGST1 NCALD NCS1 PDAP1 PRNP PSME3IP1 SGTA SGTB SLC30A4 SLC35B1 TMEM237 UBQLN1 UBQLN2 UBQLN4	9 interacting genes: APP CEBPA CSNK2A1 CWC22 FZD7 PDGFA PDGFB PDGFRB SF1
Entrez ID		8324	11333
HPRD ID		04560	06149
Ensembl ID		ENSG00000155760	ENSG00000106244
Uniprot IDs		O75084	Q13442
PDB IDs		4Z33 5T44 5URV 5WBS 6NE2 6NE4 6O3A 6O3B 8QEO 8YY8 9EPO 9EW2
Enriched GO Terms of Interacting Partners?		Postsynaptic Density GMP Kinase Activity Ionotropic Glutamate Receptor Binding Regulation Of Proteolysis GDP Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Receptor Clustering TRC Complex Positive Regulation Of ERAD Pathway Membrane Ribonucleoside Diphosphate Metabolic Process Regulation Of ERAD Pathway Nucleoside Diphosphate Metabolic Process GMP Metabolic Process Dendritic Spine Organization Kinase Binding Frizzled Binding Postsynaptic Density Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Neuron Projection Organization D1 Dopamine Receptor Binding Postsynapse Organization Plasma Membrane Positive Regulation Of Neuron Projection Arborization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Proteolysis Social Behavior Purine Ribonucleotide Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Synapse Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribonucleotide Metabolic Process Establishment Or Maintenance Of Cell Polarity Juxtaparanode Region Of Axon Cytoplasmic Microtubule Organization Ribose Phosphate Metabolic Process Cognition Cellular Response To Metal Ion Immunological Synapse Formation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cellular Response To Potassium Ion Response To Metal Ion Nucleoside Monophosphate Metabolic Process	Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Binding Platelet-derived Growth Factor Receptor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Platelet Alpha Granule Lumen Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Autophosphorylation Smooth Muscle Adaptation Positive Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Glomerular Mesangial Cell Proliferation Chemotaxis Golgi Lumen Protein Heterodimerization Activity Regulation Of Protein Autophosphorylation Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Receptor Ligand Activity Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Chemotaxis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Platelet-derived Growth Factor Stimulus Embryonic Organ Development Response To Platelet-derived Growth Factor
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