ZNF189 and PMS2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ZNF189	PMS2
Description		zinc finger protein 189	PMS1 homolog 2, mismatch repair system component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol Mismatch Repair Complex MutLalpha Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Mismatched DNA Binding Single Base Insertion Or Deletion Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes
Pathways		Generic Transcription Pathway	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
Interacting Genes		15 interacting genes: AURKA AXIN2 BMPR1A BRAF BUB1 CTNNA1 DLC1 ERBB2 KRAS MCC PMS2 RBM11 SMAD4 SRC STK11	18 interacting genes: AKT1 ANP32B CCDC180 CRYAA EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC VPS26C XPA ZNF189
Entrez ID		7743	5395
HPRD ID		11930	02598
Ensembl ID		ENSG00000136870	ENSG00000122512
Uniprot IDs		A0A087X0K2 B7ZLK9 O75820	A0A2R8Y6S3 A0A8V8TNX6 A0A8V8TNY8 A0A8V8TP61 A0A8V8TP84 A0A8V8TPE1 A0A8V8TQ50 A0A8V8TQ92 A0A8V8TQG9 A0A8V8TQI1 A0A8V8TQS5 B4DGM0 C9J167 P54278
PDB IDs			1EA6 1H7S 1H7U 5U5R 6MFQ 7RCB 7RCI 7RCK
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Development Gland Development Animal Organ Morphogenesis Protein Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process Axis Specification Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Animal Organ Development Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Odontogenesis Cell Surface Receptor Signaling Pathway Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Gene Expression Nucleotide Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Centromeric Sister Chromatid Cohesion Cell Differentiation Regulation Of Wnt Signaling Pathway Reproductive Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Protein Phosphorylation LRR Domain Binding ATP Binding Regulation Of Cellular Component Organization Negative Regulation Of Locomotion Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Negative Regulation Of Wnt Signaling Pathway Mesendoderm Development Phosphorylation Regulation Of Intracellular Signal Transduction Mitral Valve Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Developmental Process	Response To Oxidative Stress Positive Regulation Of Deoxyribonuclease Activity Mismatch Repair Response To UV Response To UV-A Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Hydrogen Peroxide DNA Repair Response To Light Stimulus Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Stress Enzyme Binding TRNA Methylation Nucleus Regulation Of TRNA Methylation Response To Radiation Response To Reactive Oxygen Species DNA Metabolic Process DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment PCNA Complex Replisome Negative Regulation Of Sodium-dependent Phosphate Transport Nucleotide-excision Repair, DNA Damage Recognition Double-stranded DNA 5'-3' DNA Exonuclease Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity Male Germ Cell Nucleus Nucleotide-excision Repair
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