ZNF189 and CTNNA1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ZNF189	CTNNA1
Description		zinc finger protein 189	catenin alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Acrosomal Vesicle Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Anchoring Junction Plasma Membrane Protein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process	Ovarian Follicle Development Apoptotic Process Cell Adhesion Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Cell Motility Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Generic Transcription Pathway	Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Malaria ( 31844061) Schizophrenia ( 25056061)
Interacting Genes		15 interacting genes: AURKA AXIN2 BMPR1A BRAF BUB1 CTNNA1 DLC1 ERBB2 KRAS MCC PMS2 RBM11 SMAD4 SRC STK11	55 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 DYRK1A EIF4ENIF1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 HSPA13 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS PKD1 PSEN1 RBM26 RNF10 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510
Entrez ID		7743	1495
HPRD ID		11930	00285
Ensembl ID		ENSG00000136870	ENSG00000044115
Uniprot IDs		A0A087X0K2 B7ZLK9 O75820	A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221
PDB IDs			1H6G 4EHP 4IGG 6UPV 6V2O 6V2P 7UTJ 9BL2 9BL3 9BL4
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Development Gland Development Animal Organ Morphogenesis Protein Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process Axis Specification Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Animal Organ Development Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Odontogenesis Cell Surface Receptor Signaling Pathway Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Gene Expression Nucleotide Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Centromeric Sister Chromatid Cohesion Cell Differentiation Regulation Of Wnt Signaling Pathway Reproductive Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Protein Phosphorylation LRR Domain Binding ATP Binding Regulation Of Cellular Component Organization Negative Regulation Of Locomotion Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Negative Regulation Of Wnt Signaling Pathway Mesendoderm Development Phosphorylation Regulation Of Intracellular Signal Transduction Mitral Valve Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Developmental Process	Cell-cell Junction Organization Cell Junction Organization Adherens Junction Cadherin Binding Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Assembly Cell Junction Cell-cell Adhesion Catenin Complex Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Alpha-catenin Binding Anchoring Junction Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fascia Adherens Anatomical Structure Morphogenesis Regulation Of Cell Motility Regulation Of Protein Localization Glutamatergic Synapse Regulation Of Locomotion Beta-catenin Binding Regulation Of Cell Migration Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Plasma Membrane Cellular Response To Indole-3-methanol Regulation Of Supramolecular Fiber Organization Cell Development Regulation Of Cell Population Proliferation Response To Indole-3-methanol Cytoplasm Cortical Actin Cytoskeleton Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Developmental Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of Angiogenesis Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Fructose 1,6-bisphosphate Metabolic Process Regulation Of RNA Metabolic Process
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