ACOX2 and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACOX2	DYNLT1
Description		acyl-CoA oxidase 2	dynein light chain Tctex-type 1
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Acyl-CoA Oxidase Activity Fatty Acid Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase Activity Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding FAD Binding Long-chain Fatty Acyl-CoA Oxidase Activity	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Beta-oxidation of pristanoyl-CoA Peroxisomal protein import Peroxisomal protein import	Neutrophil degranulation
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 28714469)
Interacting Genes		3 interacting genes: CLK1 DYNLT1 PEX5	48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		8309	6993
HPRD ID		09037	15987
Ensembl ID		ENSG00000168306	ENSG00000146425
Uniprot IDs		B4DPM1 Q99424	P63172
PDB IDs			5JPW 8J07 8PR0 8PR1 8PTK 8RGI
Enriched GO Terms of Interacting Partners?		Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Host Cell Intracellular Transport Of Virus Secretory Vesicle Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Cerebral Cortex Neuron Differentiation Cytoplasmic Dynein Complex Peroxisome Organization Receptor Recycling Protein Serine/threonine/tyrosine Kinase Activity Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of Multicellular Organism Growth Dynein Intermediate Chain Binding Dynein Complex Establishment Of Mitotic Spindle Orientation Forebrain Neuron Differentiation Establishment Of Mitotic Spindle Localization Non-membrane Spanning Protein Tyrosine Kinase Activity Telencephalon Cell Migration Establishment Of Spindle Orientation Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Establishment Of Spindle Localization Cytoplasmic Microtubule Endoplasmic Reticulum Organization Spindle Localization Peroxisomal Membrane Protein Transport Regulation Of Multicellular Organism Growth	Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion
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