DYSF and ANXA1

Number of citations of the paper that reports this interaction (PMID 14506282)
81

Data Source:
HPRD (in vitro)

		DYSF	ANXA1
Gene Name		dysferlin	annexin A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane Lamellipodium Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Sarcolemma Extracellular Vesicular Exosome	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Plasma Membrane Repair Vesicle Fusion	DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion
Pathways			G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs			Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Schizophrenia, bipolar disorder and depression (combined) ( 20713499)
Protein-Protein Interactions		4 interactors: ANXA1 ANXA2 CAPN3 CAV3	31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ
Entrez ID		8291	301
HPRD ID		04307	01060
Ensembl ID		ENSG00000135636	ENSG00000135046
Uniprot IDs		O75923	P04083 Q5TZZ9
PDB IDs			1AIN 1BO9 1QLS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Membrane Raft Assembly Membrane Raft Organization Positive Regulation Of Vesicle Fusion Membrane Assembly Membrane Biogenesis Muscle Cell Cellular Homeostasis Protein Localization To Membrane Regulation Of Vesicle Fusion Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Protein Localization Establishment Of Protein Localization To Plasma Membrane Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Neutrophil Clearance Regulation Of Nerve Growth Factor Receptor Activity Autolysis Membrane Organization Protein Localization To Plasma Membrane Regulation Of Organelle Organization Striated Muscle Cell Development Regulation Of Muscle Cell Differentiation Organ Development Regulation Of Ion Homeostasis Muscle Cell Development DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Organelle Organization Regulation Of Calcium Ion Transport Positive Regulation Of Cellular Protein Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Plasma Membrane Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Phospholipase A2 Activity G1 To G0 Transition Involved In Cell Differentiation Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration T-tubule Organization Establishment Of Protein Localization To Membrane Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process	Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?