DYSF and CAPN3

Number of citations of the paper that reports this interaction (PMID 15827562)
19

Data Source:
HPRD (in vivo)

		DYSF	CAPN3
Gene Name		dysferlin	calpain 3, (p94)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane Lamellipodium Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Sarcolemma Extracellular Vesicular Exosome	Intracellular Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein Complex
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Protein Complex Scaffold Ligase Regulator Activity
	Biological Process	Plasma Membrane Repair Vesicle Fusion	Autolysis Protein Complex Assembly Proteolysis Apoptotic Process Signal Transduction Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Myofibril Assembly Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Triglycerides ( 20686565)
Protein-Protein Interactions		4 interactors: ANXA1 ANXA2 CAPN3 CAV3	7 interactors: DYSF FLNC NECAB2 OSGIN1 TTN WDYHV1 YWHAQ
Entrez ID		8291	825
HPRD ID		04307	00255
Ensembl ID		ENSG00000135636	ENSG00000092529
Uniprot IDs		O75923	C6EVS3 C6EVS4 P20807
PDB IDs			1Y9V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Membrane Raft Assembly Membrane Raft Organization Positive Regulation Of Vesicle Fusion Membrane Assembly Membrane Biogenesis Muscle Cell Cellular Homeostasis Protein Localization To Membrane Regulation Of Vesicle Fusion Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Protein Localization Establishment Of Protein Localization To Plasma Membrane Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Neutrophil Clearance Regulation Of Nerve Growth Factor Receptor Activity Autolysis Membrane Organization Protein Localization To Plasma Membrane Regulation Of Organelle Organization Striated Muscle Cell Development Regulation Of Muscle Cell Differentiation Organ Development Regulation Of Ion Homeostasis Muscle Cell Development DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Organelle Organization Regulation Of Calcium Ion Transport Positive Regulation Of Cellular Protein Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Plasma Membrane Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Phospholipase A2 Activity G1 To G0 Transition Involved In Cell Differentiation Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration T-tubule Organization Establishment Of Protein Localization To Membrane Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process	Muscle Fiber Development Striated Muscle Cell Development Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development Directional Locomotion Myosin Filament Assembly Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Plasma Membrane Repair Muscle Cell Differentiation
Tagcloud ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst
Tagcloud (Difference) ?		albeit aneusomies breaks calpain cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst
Tagcloud (Intersection) ?		capn3