DYSF and ANXA2

Number of citations of the paper that reports this interaction (PMID 14506282)
81

Data Source:
HPRD (in vitro)

		DYSF	ANXA2
Gene Name		dysferlin	annexin A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane Lamellipodium Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Sarcolemma Extracellular Vesicular Exosome	Ruffle Basement Membrane Extracellular Space Nucleus Lysosomal Membrane Endosome Early Endosome Lipid Particle Plasma Membrane Cell Cortex Cell Surface Membrane Extrinsic Component Of Plasma Membrane Midbody Extracellular Matrix Late Endosome Membrane Vesicle Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Protein Complex Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Rab GTPase Binding Phospholipase A2 Inhibitor Activity S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Plasma Membrane Repair Vesicle Fusion	Angiogenesis Membrane Raft Assembly Positive Regulation Of Protein Phosphorylation Membrane Budding Body Fluid Secretion Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Osteoclast Development Fibrinolysis Negative Regulation Of Catalytic Activity Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Binding Protein Heterotetramerization Protein Targeting To Plasma Membrane
Pathways			Dissolution of Fibrin Clot Orphan transporters
Drugs			Tenecteplase
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: ANXA1 ANXA2 CAPN3 CAV3	31 interactors: APOH APP CD99 CDC42 CEACAM1 CTSB DYSF GRB2 HMGA1 LGALS13 LYPLA1 MAP3K4 MYOC PHB PLA1A PLAT PLG POT1 PRKCA PRKCB S100A10 S100A4 S100A6 SOS1 SRC STAT6 TERF1 TERT TP53 TRPV5 YWHAQ
Entrez ID		8291	302
HPRD ID		04307	01061
Ensembl ID		ENSG00000135636	ENSG00000182718
Uniprot IDs		O75923	P07355
PDB IDs			1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Membrane Raft Assembly Membrane Raft Organization Positive Regulation Of Vesicle Fusion Membrane Assembly Membrane Biogenesis Muscle Cell Cellular Homeostasis Protein Localization To Membrane Regulation Of Vesicle Fusion Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Protein Localization Establishment Of Protein Localization To Plasma Membrane Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Neutrophil Clearance Regulation Of Nerve Growth Factor Receptor Activity Autolysis Membrane Organization Protein Localization To Plasma Membrane Regulation Of Organelle Organization Striated Muscle Cell Development Regulation Of Muscle Cell Differentiation Organ Development Regulation Of Ion Homeostasis Muscle Cell Development DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Organelle Organization Regulation Of Calcium Ion Transport Positive Regulation Of Cellular Protein Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Plasma Membrane Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Phospholipase A2 Activity G1 To G0 Transition Involved In Cell Differentiation Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration T-tubule Organization Establishment Of Protein Localization To Membrane Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process	Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Cellular Component Biogenesis Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization ERBB Signaling Pathway Cell Activation Regulation Of Signaling Telomere Maintenance Via Telomerase Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Developmental Process Regulation Of Apoptotic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway Cell Aging Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA-dependent DNA Replication Regulation Of ERBB Signaling Pathway Age-dependent Telomere Shortening Telomere Formation Via Telomerase Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Immune System Process Cell Migration Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Organization
Tagcloud ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Difference) ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Intersection) ?