DYSF and CAV3

Number of citations of the paper that reports this interaction (PubMedID 11532985)
0

Data Source:
HPRD (in vitro, in vivo)

		DYSF	CAV3
Description		dysferlin	caveolin 3
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Centriolar Satellite Sarcolemma Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc T-tubule Neuromuscular Junction Vesicle Protein-containing Complex Sarcolemma Membrane Raft
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Lipid Binding Metal Ion Binding	Calcium Channel Regulator Activity Protein Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Enzyme Binding Alpha-tubulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding
	Biological Process	Monocyte Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Regulation Of Neurotransmitter Secretion Negative Regulation Of Phagocytosis	MAPK Cascade Response To Hypoxia Plasma Membrane Repair Regulation Of Heart Rate Response To Ischemia Cardiac Muscle Hypertrophy Triglyceride Metabolic Process Calcium Ion Transport Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Myotube Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Cytosolic Calcium Ion Concentration Nucleus Localization Establishment Of Localization In Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ionomycin Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Smooth Muscle Contraction Smooth Muscle Contraction	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases		Dysferlinopathies, including: Miyoshi myopathy (MM); Limb-girdle muscular dystrophy (LGMD) 2B; Distal myopathy with anterior tibial onset (DMAT) Limb-girdle muscular dystrophy (LGMD) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)	Limb-girdle muscular dystrophy (LGMD) Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Appendicular lean mass ( 33097823) Asthma ( 32296059) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 28552196 34021172) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Protein quantitative trait loci ( 18464913) Urate levels in overweight individuals ( 25811787)	Caudate activity during reward ( 28927378) Takayasu arteritis ( 33308445)
Interacting Genes		40 interacting genes: AKAP1 ANKRD1 ANXA1 ANXA2 APPL1 CAPN3 CAV3 CMYA5 COL12A1 COL6A3 DGKD DHX15 DNAJB6 EEF1A1 EEF1G FAM120A GNL3 KARS1 KIF1B MORF4L1 MYBPC1 MYBPC2 MYH3 MYOM1 MYOM2 NPHP3 OPTN OS9 PHF1 PLP1 RNF10 RNF2 SAMHD1 SGCG SLC12A6 SNAPIN TAF1 XIRP2 XRCC6 ZNF23	21 interacting genes: ADRB2 DAG1 DYSF EGFR GNAS INSR JPH2 KCNJ12 NOS1 PBX3 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RBFA RYR1 SENP1 SLC22A11 SLC8A1 SNCA
Entrez ID		8291	859
HPRD ID		04307	03154
Ensembl ID		ENSG00000135636	ENSG00000182533
Uniprot IDs		O75923	P56539
PDB IDs		4CAH 4CAI 4IHB 4IQH 7JOF 7K6B 7KRB 9B8K 9B8L
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Myosin Filament M Band Actin Cytoskeleton Organization Actomyosin Structure Organization Muscle Organ Development Actin Filament-based Process Muscle Structure Development Structural Constituent Of Muscle Cellular Response To Salt Stress Titin Binding Myofibril Sarcolemma Cytoskeleton Organization Response To Salt Stress Extraocular Skeletal Muscle Development Organelle Organization Positive Regulation Of Transport Vesicle Membrane Kinase Binding Phospholipase A2 Inhibitor Activity Phospholipase Inhibitor Activity Cellular Response To Osmotic Stress Z Disc Phosphatidylserine Binding Membrane Raft Assembly Cytoplasmic Side Of Lysosomal Membrane Positive Regulation Of Endocytosis Response To Osmotic Stress Anterograde Synaptic Vesicle Transport Cadherin Binding Involved In Cell-cell Adhesion Translation Elongation Factor Activity Positive Regulation Of Vesicle Fusion Skeletal Muscle Organ Development Regulation Of Protein Localization Retrograde Axonal Transport	Regulation Of System Process Sarcolemma T-tubule Muscle System Process Regulation Of Monoatomic Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Transport Regulation Of Muscle Contraction Muscle Contraction Receptor Complex Regulation Of Metal Ion Transport System Process Negative Regulation Of Serotonin Uptake Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Regulation Of Calcium Ion Transport Regulation Of Serotonin Uptake Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Endothelial Growth Factor Binding Homeostatic Process Regulation Of Muscle System Process Sarcoplasmic Reticulum Membrane Positive Regulation Of The Force Of Heart Contraction Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Regulation Of Sequestering Of Calcium Ion Plasma Membrane Z Disc Glomerular Capillary Formation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Response To Growth Factor Positive Regulation Of Transport Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chemical Homeostasis Calcium-mediated Signaling Cellular Response To Oxygen-containing Compound Junctional Sarcoplasmic Reticulum Membrane Cellular Response To Caffeine Apical Plasma Membrane Positive Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Sarcoplasmic Reticulum Platelet-derived Growth Factor Binding Regulation Of Heart Contraction
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