DYSF and CAV3

Number of citations of the paper that reports this interaction (PMID 11532985)
35

Data Source:
HPRD (in vivo, in vitro)

		DYSF	CAV3
Gene Name		dysferlin	caveolin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Membrane Lamellipodium Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Sarcolemma Extracellular Vesicular Exosome	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Z Disc T-tubule Neuromuscular Junction Vesicle Sarcolemma Membrane Raft
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	Calcium Channel Regulator Activity Protein Binding Protein C-terminus Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Protein Complex Binding Protein Complex Scaffold Alpha-tubulin Binding Ion Channel Binding Nitric-oxide Synthase Binding Connexin Binding
	Biological Process	Plasma Membrane Repair Vesicle Fusion	Plasma Membrane Repair Regulation Of Heart Rate Negative Regulation Of Protein Kinase Activity Triglyceride Metabolic Process Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Cell Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Muscle Cell Cellular Homeostasis Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nerve Growth Factor Receptor Activity Nucleus Localization Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Import Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		4 interactors: ANXA1 ANXA2 CAPN3 CAV3	15 interactors: DAG1 DYSF EGFR GNAS INSR JPH2 NOS1 PCBP1 PDGFRA PDGFRB PFKM PTGES3 SENP1 SLC22A11 SLC8A1
Entrez ID		8291	859
HPRD ID		04307	03154
Ensembl ID		ENSG00000135636	ENSG00000182533
Uniprot IDs		O75923	P56539
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Membrane Raft Assembly Membrane Raft Organization Positive Regulation Of Vesicle Fusion Membrane Assembly Membrane Biogenesis Muscle Cell Cellular Homeostasis Protein Localization To Membrane Regulation Of Vesicle Fusion Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Protein Localization Establishment Of Protein Localization To Plasma Membrane Regulation Of Catalytic Activity Cellular Localization Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Neutrophil Clearance Regulation Of Nerve Growth Factor Receptor Activity Autolysis Membrane Organization Protein Localization To Plasma Membrane Regulation Of Organelle Organization Striated Muscle Cell Development Regulation Of Muscle Cell Differentiation Organ Development Regulation Of Ion Homeostasis Muscle Cell Development DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Organelle Organization Regulation Of Calcium Ion Transport Positive Regulation Of Cellular Protein Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Plasma Membrane Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Phospholipase A2 Activity G1 To G0 Transition Involved In Cell Differentiation Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration T-tubule Organization Establishment Of Protein Localization To Membrane Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process	Homeostatic Process Chemical Homeostasis Wound Healing Organ Morphogenesis Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Metabolic Process Positive Regulation Of The Force Of Heart Contraction Response To Wounding Positive Regulation Of Transport Exocrine System Development Regulation Of Calcium Ion Transport Positive Regulation Of Phospholipase C Activity Response To Organonitrogen Compound Glomerular Capillary Formation Cellular Response To Organonitrogen Compound Protein Autophosphorylation Cardiac Muscle Cell Development Positive Regulation Of DNA Replication Striated Muscle Cell Differentiation Metanephric Glomerulus Vasculature Development Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Metanephric Glomerulus Development Glomerulus Morphogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Interaction With Host Anatomical Structure Morphogenesis Tissue Development Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Cellular Component Movement Response To Organic Substance Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion
Tagcloud ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable
Tagcloud (Difference) ?		albeit aneusomies breaks calpain capn3 cdkn2a combat convergent dmd duplications dysferlin dystrophies dystrophin dystrophy fibro gross liposarcomas md muscular nf1 pathologies pathomechanism regularly rhabdomyo sarcoma sarcomas share suppressors wasting	ca2 caco constraining delineated driving exceeded heightened ikb immunoreactivity influx interstitial intratumoral invoke kb mechanosensitive mll mmhg pc3 peripheries phospho pkc potentiates pressure pressures stiff stimulate stroma sw620 unresectable
Tagcloud (Intersection) ?