CAPN3 and NECAB2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CAPN3	NECAB2
Gene Name		calpain 3, (p94)	N-terminal EF-hand calcium binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein Complex	Cytoplasm
	Molecular Function	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Protein Complex Scaffold Ligase Regulator Activity	Calcium Ion Binding Protein Binding
	Biological Process	Autolysis Protein Complex Assembly Proteolysis Apoptotic Process Signal Transduction Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Myofibril Assembly Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis
Pathways
Drugs
Diseases
GWAS		Triglycerides ( 20686565)
Protein-Protein Interactions		7 interactors: DYSF FLNC NECAB2 OSGIN1 TTN WDYHV1 YWHAQ	53 interactors: AIMP2 BEX2 BYSL C1orf109 CAPN3 CARD9 CCDC146 CCDC151 CCDC153 CCDC33 CCNK CENPO DAXX DFFA DGCR6 DGCR6L EHHADH EIF4E2 FAM161A FXR2 GCC1 GTPBP10 HAUS1 INPP1 ISCU KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 NEK6 NGFRAP1 NIP7 NOC4L PRKAA2 PSMA1 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SSC5D TEX11 TTC25 TTR USP7 VTA1 WDYHV1
Entrez ID		825	54550
HPRD ID		00255	13263
Ensembl ID		ENSG00000092529	ENSG00000103154
Uniprot IDs		C6EVS3 C6EVS4 P20807	Q7Z6G3
PDB IDs		1Y9V
Enriched GO Terms of Interacting Partners?		Muscle Fiber Development Striated Muscle Cell Development Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development Directional Locomotion Myosin Filament Assembly Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Plasma Membrane Repair Muscle Cell Differentiation	Organelle Organization Cell Cycle Regulation Of Apoptotic Process Apoptotic Process Ribosome Biogenesis Regulation Of Cell Death Programmed Cell Death Regulation Of Protein Metabolic Process Cell Cycle Process Cellular Component Assembly Cell Death Death Chromatin Modification Regulation Of Cellular Protein Metabolic Process Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA Positive Regulation Of JNK Cascade Organelle Assembly Cell-cell Adhesion Involved In Gastrulation Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Apoptotic DNA Fragmentation Nitrogen Fixation Autolysis Chromatin Organization Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Tagcloud ?		accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst
Tagcloud (Difference) ?		accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst
Tagcloud (Intersection) ?