CAPN3 and FLNC

Number of citations of the paper that reports this interaction (PMID 14506720)
14

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, in vitro)

		CAPN3	FLNC
Gene Name		calpain 3, (p94)	filamin C, gamma
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Protein Complex Scaffold Ligase Regulator Activity	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Autolysis Protein Complex Assembly Proteolysis Apoptotic Process Signal Transduction Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Myofibril Assembly Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Triglycerides ( 20686565)
Protein-Protein Interactions		7 interactors: DYSF FLNC NECAB2 OSGIN1 TTN WDYHV1 YWHAQ	29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		825	2318
HPRD ID		00255	00018
Ensembl ID		ENSG00000092529	ENSG00000128591
Uniprot IDs		C6EVS3 C6EVS4 P20807	Q14315 Q59H94
PDB IDs		1Y9V	1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Muscle Fiber Development Striated Muscle Cell Development Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development Directional Locomotion Myosin Filament Assembly Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Plasma Membrane Repair Muscle Cell Differentiation	Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation
Tagcloud ?		accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?		accompanying amputated amputation def defhi429 dexamethasone digestive distortion epidermis fibrotic firstly haploinsufficiency hepatectomy hepatocyte heteroozygous leaving leukocytes metazoan nucleolar nucleolus regenerate regeneration remarkable sb431542 scar suffers tgfbeta whilst	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?