VANGL1 and SMYD3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		VANGL1	SMYD3
Gene Name		VANGL planar cell polarity protein 1	SET and MYND domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Lateral Plasma Membrane	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Multicellular Organismal Development	Chromatin Organization Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Dexamethasone Stimulus
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CD82 DVL1 DVL2 DVL3 GMFG NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2	16 interactors: APP CAMK2B CYP39A1 EED EZH2 H3F3C HELZ HIST3H3 HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K TRIT1 VANGL1 ZNF557
Entrez ID		81839	64754
HPRD ID		18279	12297
Ensembl ID		ENSG00000173218	ENSG00000185420
Uniprot IDs		Q8TAA9	B3KN46 Q9H7B4
PDB IDs			3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cochlea Development Convergent Extension Involved In Organogenesis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neural Plate Morphogenesis Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis Regulation Of Protein Phosphorylation Convergent Extension Neural Plate Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Catalytic Activity Regulation Of Phosphorylation Inner Ear Development Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Kinase Activity Ear Development Wnt Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Embryonic Organ Morphogenesis Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Outflow Tract Morphogenesis Morphogenesis Of An Epithelial Sheet Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Positive Regulation Of Protein Metabolic Process Embryonic Organ Development Heart Development Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Inhibitory G-protein Coupled Receptor Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Activation Of Meiosis Involved In Egg Activation Innate Immune Response Regulation Of Synapse Structure Or Activity Cellular Metabolic Process Bile Acid Catabolic Process Collateral Sprouting In Absence Of Injury Response To Heat Transcription, DNA-templated Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Protein Import Into Mitochondrial Outer Membrane Activation Of Meiosis Cholesterol Metabolic Process Histone Methylation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Protein Lipoylation Sterol Metabolic Process Neuromuscular Process Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Synaptic Transmission, Cholinergic Axon Choice Point Recognition
Tagcloud ?		21mt 21nt 21pt 21t ap atypical blocked colony ductal extravasation hyperplasia invasion knockdown lowest malignancy mammary migration mmp3 modulate overexpression partially pcp planar polarity promote prototypical rhoa spherical wnt5a	blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Difference) ?		21mt 21nt 21pt 21t ap atypical colony ductal extravasation hyperplasia invasion knockdown lowest malignancy mammary migration mmp3 modulate overexpression partially pcp planar polarity promote prototypical rhoa spherical wnt5a	bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle
Tagcloud (Intersection) ?		blocked