VANGL1 and RAPGEF5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		VANGL1	RAPGEF5
Name		VANGL planar cell polarity protein 1	Rap guanine nucleotide exchange factor 5
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Lateral Plasma Membrane	Nucleus Nucleoplasm Plasma Membrane Nuclear Body
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding
	Biological Process	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway Mucociliary Clearance	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	None
Diseases		Spina bifida Caudal regression syndrome and Sirenomelia	None
GWAS		Coronary artery disease ( 33020668 ) Gut microbiota (bacterial taxa) ( 27694959 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Optic disc size ( 31809533 )	Asthma ( 34103634 ) Cutaneous malignant melanoma ( 32341527 ) Depression in smokers ( 30219690 ) Dialysis-related mortality ( 21546767 ) Diastolic blood pressure ( 30224653 ) Gamma glutamyl transferase levels ( 33339817 ) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699 ) Night sleep phenotypes ( 27126917 ) Spatial processing ( 31596458 ) Squamous cell lung carcinoma ( 28604730 ) Thyroid stimulating hormone levels ( 17903292 ) Urinary albumin excretion ( 32277301 )
Novel Interactors		1 novel interactors: FES	1 novel interactors: ITGB8
Interacting Genes		12 interacting genes: CD82 DVL1 DVL2 DVL3 GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2 UBC	7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		81839	9771
HPRD ID		18279	15208
Ensembl ID		ENSG00000173218	ENSG00000136237
Uniprot IDs		Q8TAA9	A0A0S2Z561 A8MQ07 Q92565
PDB IDs		8ZXD 9JK6 9JK8 9JK9	1WGY
GO Terms Enriched among Interactors		Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Convergent Extension Involved In Neural Plate Elongation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Convergent Extension Involved In Organogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Gastrulation Regulation Of Cell Morphogenesis Convergent Extension Canonical Wnt Signaling Pathway Positive Regulation Of Cell Projection Organization Cochlea Morphogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Localization To Presynapse Wnt Signaling Pathway Small GTPase Binding Clathrin-coated Vesicle Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cell Projection Organization Actin Filament Debranching TRNA 2'-phosphotransferase Activity Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Beta-catenin Binding Nuclear Body Regulation Of Actin Filament-based Process Positive Regulation Of JNK Cascade Phosphorylation Epithelial Tube Morphogenesis Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Histone H3K36 Dimethyltransferase Activity	Rap Protein Signal Transduction GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Bounding Membrane Of Organelle Establishment Of Endothelial Barrier Endothelial Cell Development Intracellular Signaling Cassette Specific Granule Membrane Integrin Alphav-beta8 Complex Response To Antineoplastic Agent Recycling Endosome Membrane Epithelial Cell Development Langerhans Cell Differentiation Recycling Endosome Extracellular Matrix Protein Binding Positive Regulation Of Microvillus Assembly Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Cytoplasmic Vesicle Membrane