VANGL1 and RAPGEF5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		VANGL1	RAPGEF5
Gene Name		VANGL planar cell polarity protein 1	Rap guanine nucleotide exchange factor (GEF) 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Lateral Plasma Membrane	Nucleus
	Molecular Function	Protein Binding	Ras Guanyl-nucleotide Exchange Factor Activity Rap Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process	Multicellular Organismal Development	Small GTPase Mediated Signal Transduction Nervous System Development Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity
Pathways
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Thyroid stimulating hormone ( 17903292)
Protein-Protein Interactions		10 interactors: CD82 DVL1 DVL2 DVL3 GMFG NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2	7 interactors: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		81839	9771
HPRD ID		18279	15208
Ensembl ID		ENSG00000173218	ENSG00000136237
Uniprot IDs		Q8TAA9	A8MQ07 Q5JPD2 Q92565
PDB IDs			1WGY
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cochlea Development Convergent Extension Involved In Organogenesis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neural Plate Morphogenesis Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis Regulation Of Protein Phosphorylation Convergent Extension Neural Plate Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Catalytic Activity Regulation Of Phosphorylation Inner Ear Development Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Kinase Activity Ear Development Wnt Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Embryonic Organ Morphogenesis Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Outflow Tract Morphogenesis Morphogenesis Of An Epithelial Sheet Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Positive Regulation Of Protein Metabolic Process Embryonic Organ Development Heart Development Positive Regulation Of Transcription, DNA-templated	Rap Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Autophosphorylation Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Platelet Activation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Vasculogenesis Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Blood Coagulation Hemostasis Microvillus Assembly Negative Regulation Of Synaptic Vesicle Exocytosis Microvillus Organization Regulation Of Vasculogenesis Positive Regulation Of Rap GTPase Activity Regulation Of Cell Projection Organization Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Differentiation Regulation Of Rap Protein Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Establishment Of Endothelial Barrier Wound Healing Actin Cytoskeleton Organization Regulation Of MAPK Cascade Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Exocytosis Actin Filament-based Process Regulation Of Locomotion Cell Activation
Tagcloud ?		21mt 21nt 21pt 21t ap atypical blocked colony ductal extravasation hyperplasia invasion knockdown lowest malignancy mammary migration mmp3 modulate overexpression partially pcp planar polarity promote prototypical rhoa spherical wnt5a
Tagcloud (Difference) ?		21mt 21nt 21pt 21t ap atypical blocked colony ductal extravasation hyperplasia invasion knockdown lowest malignancy mammary migration mmp3 modulate overexpression partially pcp planar polarity promote prototypical rhoa spherical wnt5a
Tagcloud (Intersection) ?