VANGL1 and DVL3

Number of citations of the paper that reports this interaction (PMID 15456783)
44

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		VANGL1	DVL3
Gene Name		VANGL planar cell polarity protein 1	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Lateral Plasma Membrane	Cytosol
	Molecular Function	Protein Binding	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	Multicellular Organismal Development	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		10 interactors: CD82 DVL1 DVL2 DVL3 GMFG NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		81839	1857
HPRD ID		18279	03222
Ensembl ID		ENSG00000173218	ENSG00000161202
Uniprot IDs		Q8TAA9	Q92997
PDB IDs
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cochlea Development Convergent Extension Involved In Organogenesis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neural Plate Morphogenesis Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis Regulation Of Protein Phosphorylation Convergent Extension Neural Plate Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Organ Morphogenesis Regulation Of Catalytic Activity Regulation Of Phosphorylation Inner Ear Development Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Kinase Activity Ear Development Wnt Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Embryonic Organ Morphogenesis Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Outflow Tract Morphogenesis Morphogenesis Of An Epithelial Sheet Positive Regulation Of Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of JUN Kinase Activity Positive Regulation Of Protein Metabolic Process Embryonic Organ Development Heart Development Positive Regulation Of Transcription, DNA-templated	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?		21mt 21nt 21pt 21t ap atypical blocked colony ductal extravasation hyperplasia invasion knockdown lowest malignancy mammary migration mmp3 modulate overexpression partially pcp planar polarity promote prototypical rhoa spherical wnt5a	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		21mt 21nt 21pt 21t ap atypical blocked colony ductal extravasation hyperplasia invasion knockdown lowest malignancy mammary migration mmp3 modulate overexpression partially pcp planar polarity promote prototypical rhoa spherical wnt5a	achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?