VANGL1 and THAP2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		VANGL1	THAP2
Name		VANGL planar cell polarity protein 1	THAP domain containing 2
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Lateral Plasma Membrane	Nucleus Nucleolus
	Molecular Function	Protein Binding	DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway Mucociliary Clearance	None
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	None
Diseases		Spina bifida Caudal regression syndrome and Sirenomelia	None
GWAS		Coronary artery disease ( 33020668 ) Gut microbiota (bacterial taxa) ( 27694959 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Optic disc size ( 31809533 )	Economic and political preferences (time) ( 22566634 )
Novel Interactors		1 novel interactors: FES	None recorded
Interacting Genes		12 interacting genes: CD82 DVL1 DVL2 DVL3 GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2 UBC	2 interacting genes: PTPN12 VANGL1
Entrez ID		81839	83591
HPRD ID		18279	10896
Ensembl ID		ENSG00000173218	ENSG00000173451
Uniprot IDs		Q8TAA9	Q9H0W7
PDB IDs		8ZXD 9JK6 9JK8 9JK9	2D8R
GO Terms Enriched among Interactors		Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Convergent Extension Involved In Neural Plate Elongation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Convergent Extension Involved In Organogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Gastrulation Regulation Of Cell Morphogenesis Convergent Extension Canonical Wnt Signaling Pathway Positive Regulation Of Cell Projection Organization Cochlea Morphogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Localization To Presynapse Wnt Signaling Pathway Small GTPase Binding Clathrin-coated Vesicle Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cell Projection Organization Actin Filament Debranching TRNA 2'-phosphotransferase Activity Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Beta-catenin Binding Nuclear Body Regulation Of Actin Filament-based Process Positive Regulation Of JNK Cascade Phosphorylation Epithelial Tube Morphogenesis Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Histone H3K36 Dimethyltransferase Activity	Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mucociliary Clearance Negative Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Podosome Response To Epidermal Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Tissue Regeneration Extracellular Transport Epithelial Cilium Movement Involved In Extracellular Fluid Movement Non-canonical Wnt Signaling Pathway Pigmentation Respiratory System Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lateral Plasma Membrane Regulation Of ERBB Signaling Pathway Protein Dephosphorylation Protein Tyrosine Phosphatase Activity SH3 Domain Binding Regeneration Dephosphorylation