VANGL1 and GMFG

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		VANGL1	GMFG
Name		VANGL planar cell polarity protein 1	glia maturation factor gamma
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Lateral Plasma Membrane	Extracellular Region Cortical Actin Cytoskeleton Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Actin Binding Protein Kinase Inhibitor Activity Enzyme Activator Activity Growth Factor Activity Arp2/3 Complex Binding
	Biological Process	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway Mucociliary Clearance	Protein Phosphorylation Signal Transduction Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Debranching
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Neutrophil degranulation
Diseases		Spina bifida Caudal regression syndrome and Sirenomelia	None
GWAS		Coronary artery disease ( 33020668 ) Gut microbiota (bacterial taxa) ( 27694959 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Optic disc size ( 31809533 )	Lung adenocarcinoma ( 28604730 )
Novel Interactors		1 novel interactors: FES	1 novel interactors: PTGIS
Interacting Genes		12 interacting genes: CD82 DVL1 DVL2 DVL3 GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2 UBC	4 interacting genes: CAMK1D CEBPA PSD VANGL1
Entrez ID		81839	9535
HPRD ID		18279	06821
Ensembl ID		ENSG00000173218	ENSG00000130755
Uniprot IDs		Q8TAA9	M0R0C1 M0R1D2 O60234
PDB IDs		8ZXD 9JK6 9JK8 9JK9	3L50
GO Terms Enriched among Interactors		Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Convergent Extension Involved In Neural Plate Elongation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Convergent Extension Involved In Organogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Gastrulation Regulation Of Cell Morphogenesis Convergent Extension Canonical Wnt Signaling Pathway Positive Regulation Of Cell Projection Organization Cochlea Morphogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Localization To Presynapse Wnt Signaling Pathway Small GTPase Binding Clathrin-coated Vesicle Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cell Projection Organization Actin Filament Debranching TRNA 2'-phosphotransferase Activity Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Beta-catenin Binding Nuclear Body Regulation Of Actin Filament-based Process Positive Regulation Of JNK Cascade Phosphorylation Epithelial Tube Morphogenesis Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Histone H3K36 Dimethyltransferase Activity	None