MADCAM1 and ITGA4

Number of citations of the paper that reports this interaction (PMID 10702270)
3

Data Source:
HPRD (in vitro)

		MADCAM1	ITGA4
Gene Name		mucosal vascular addressin cell adhesion molecule 1	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha4-beta7 Complex Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Involved In Cell-matrix Adhesion	Fibronectin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Immune Response Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Aging Extracellular Matrix Organization Keratinocyte Differentiation Heterotypic Cell-cell Adhesion Receptor Clustering Regulation Of Immune Response Leukocyte Tethering Or Rolling	Blood Vessel Remodeling Cell-matrix Adhesion Involved In Ameboidal Cell Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Face Development Chorio-allantoic Fusion T Cell Migration Negative Regulation Of Protein Homodimerization Activity
Pathways			Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs			Natalizumab Tinzaparin
Diseases
GWAS			Celiac disease ( 20190752) Monocyte count ( 23314186) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		3 interactors: CD44 ITGA4 ITGB7	16 interactors: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		8174	3676
HPRD ID		00035	01894
Ensembl ID		ENSG00000099866	ENSG00000115232
Uniprot IDs		Q13477	P13612
PDB IDs		1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9	3V4P 3V4V 4HKC
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell-matrix Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Migration T Cell Migration Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Lymphocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Cellular Extravasation Substrate Adhesion-dependent Cell Spreading Single Organismal Cell-cell Adhesion Receptor Clustering Cell Migration Cell Motility Integrin-mediated Signaling Pathway Cell Adhesion Locomotion Ameboidal-type Cell Migration Positive Regulation Of Monocyte Aggregation Movement Of Cell Or Subcellular Component Monocyte Aggregation Negative Regulation Of Protein Homodimerization Activity Protein Localization To Membrane Immune System Process Wound Healing Involved In Inflammatory Response Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Chorio-allantoic Fusion Positive Regulation Of Heterotypic Cell-cell Adhesion Reproductive Structure Development Reproductive System Development Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Hyaluronan Catabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Wound Healing Cell Surface Receptor Signaling Pathway Regulation Of Protein Homodimerization Activity Response To Wounding Branching Involved In Prostate Gland Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Developmental Process Involved In Reproduction Cell Morphogenesis Involved In Differentiation Labyrinthine Layer Morphogenesis Negative Regulation Of Signal Transduction By P53 Class Mediator	Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Leukocyte Tethering Or Rolling Cell-substrate Adhesion Leukocyte Migration Heterotypic Cell-cell Adhesion Regulation Of Immune System Process Integrin-mediated Signaling Pathway Cellular Extravasation Formation Of Primary Germ Layer Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Viral Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Entry Into Host Cell Positive Regulation Of Protein Metabolic Process Gastrulation Locomotion Cell Junction Assembly Cell Differentiation Cell Migration Cell Motility Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Mesoderm Formation Activation Of Protein Kinase Activity Mesoderm Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Interaction With Host Tissue Development Activation Of Protein Kinase A Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Mesoderm Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Cardiovascular System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Anatomical Structure Development ERBB Signaling Pathway Renal Water Homeostasis
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