NECTIN4 and AFDN

Number of citations of the paper that reports this interaction (PubMedID 11544254)
0

Data Source:
HPRD (in vitro)

		NECTIN4	AFDN
Description		nectin cell adhesion molecule 4	afadin, adherens junction formation factor
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Extracellular Exosome Anchoring Junction	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding Receptor Ligand Activity Cell Adhesion Mediator Activity	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		Enfortumab vedotin	(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases		Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS			Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT	39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		81607	4301
HPRD ID		17934	01164
Ensembl ID		ENSG00000143217	ENSG00000130396
Uniprot IDs		K4PZ75 Q96NY8	A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		4FRW 4GJT 4JJH	1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
Enriched GO Terms of Interacting Partners?		Cell-cell Contact Zone Cell Adhesion Molecule Binding Apical Junction Complex Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor Activity Regulation Of Natural Killer Cell Mediated Immunity Immune Response Virus Receptor Activity Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Leukocyte Mediated Cytotoxicity Cell-cell Adhesion Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Sperm Mitochondrion Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Presynaptic Membrane Innate Immune Response Leukocyte Mediated Immunity Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Identical Protein Binding Membrane Curvature Sensor Activity Defense Response To Symbiont Cell-cell Junction Organization Defense Response To Other Organism Adherens Junction Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Killing Regulation Of Lymphocyte Mediated Immunity Actin Filament Binding Cell-cell Junction Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Adhesion Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Immune Response Positive Regulation Of Mast Cell Activation Growth Cone Membrane Zonula Adherens	Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
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