PVRL4

Gene Name		poliovirus receptor-related 4
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding
	Biological Process	Cell Adhesion Viral Process Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: MLLT4 PICK1 PVRL1 PVRL2 TIGIT
Entrez ID		81607
HPRD ID		17934
Ensembl ID		ENSG00000143217
Uniprot IDs		K4PZ75 Q96NY8
PDB IDs		4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Viral Entry Into Host Cell Entry Into Host Cell Cell Development Interaction With Host Coreceptor-mediated Virion Attachment To Host Cell Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Fusion Of Virus Membrane With Host Plasma Membrane Viral Life Cycle Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Projection Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Cell Adhesion Establishment Of Endothelial Intestinal Barrier Enamel Mineralization Virion Attachment To Host Cell DNA Methylation Involved In Embryo Development Positive Regulation Of Immune Response To Tumor Cell Dendritic Spine Maintenance Adhesion Of Symbiont To Host Cell Differentiation Tooth Mineralization Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Desmosome Organization Positive Regulation Of Mast Cell Activation Negative Regulation Of Actin Nucleation Acrosome Assembly Amelogenesis Establishment Of Mitochondrion Localization Positive Regulation Of Rap GTPase Activity Long Term Synaptic Depression Regulation Of Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Component Assembly Negative Regulation Of Interleukin-12 Production Dendritic Spine Organization Regulation Of Rap GTPase Activity DNA Methylation Involved In Gamete Generation
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