NECTIN4

Description		nectin cell adhesion molecule 4
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding Receptor Ligand Activity Cell Adhesion Mediator Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		Enfortumab vedotin
Diseases		Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS
Interacting Genes		6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		81607
HPRD ID		17934
Ensembl ID		ENSG00000143217
Uniprot IDs		K4PZ75 Q96NY8
PDB IDs		4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?		Cell-cell Contact Zone Cell Adhesion Molecule Binding Apical Junction Complex Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor Activity Regulation Of Natural Killer Cell Mediated Immunity Immune Response Virus Receptor Activity Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Leukocyte Mediated Cytotoxicity Cell-cell Adhesion Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Sperm Mitochondrion Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Presynaptic Membrane Innate Immune Response Leukocyte Mediated Immunity Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Identical Protein Binding Membrane Curvature Sensor Activity Defense Response To Symbiont Cell-cell Junction Organization Defense Response To Other Organism Adherens Junction Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Killing Regulation Of Lymphocyte Mediated Immunity Actin Filament Binding Cell-cell Junction Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Adhesion Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Immune Response Positive Regulation Of Mast Cell Activation Growth Cone Membrane Zonula Adherens
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