NECTIN4 and TIGIT

Number of citations: 0 (PubMedID 21982860)
Data Source: BioGRID (pull down)

		NECTIN4	TIGIT
Name		nectin cell adhesion molecule 4	T cell immunoreceptor with Ig and ITIM domains
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Extracellular Exosome Anchoring Junction	Plasma Membrane Cell Surface Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding Receptor Ligand Activity Cell Adhesion Mediator Activity	Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Activation
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	None
Drugs		Enfortumab vedotin	None
Diseases		Ectodermal dysplasia-syndactyly syndrome (EDSS)	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT	6 interacting genes: MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR
Entrez ID		81607	201633
HPRD ID		17934	08804
Ensembl ID		ENSG00000143217	ENSG00000181847
Uniprot IDs		K4PZ75 Q96NY8	Q495A1
PDB IDs		4FRW 4GJT 4JJH	3Q0H 3RQ3 3UCR 3UDW 5V52 7VYT 8JEL 8JEN 8JEO 8SZY
GO Terms Enriched among Interactors		Cell-cell Contact Zone Cell Adhesion Molecule Binding Apical Junction Complex Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor Activity Regulation Of Natural Killer Cell Mediated Immunity Immune Response Virus Receptor Activity Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Leukocyte Mediated Cytotoxicity Cell-cell Adhesion Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Lymphocyte Mediated Immunity Sperm Mitochondrion Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Presynaptic Membrane Innate Immune Response Leukocyte Mediated Immunity Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Identical Protein Binding Membrane Curvature Sensor Activity Defense Response To Symbiont Cell-cell Junction Organization Defense Response To Other Organism Adherens Junction Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Killing Regulation Of Lymphocyte Mediated Immunity Actin Filament Binding Cell-cell Junction Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Adhesion Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Immune Response Positive Regulation Of Mast Cell Activation Growth Cone Membrane Zonula Adherens	Cell Adhesion Mediator Activity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Structural Constituent Of Myelin Sheath Virus Receptor Activity Cell Adhesion Molecule Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Receptor Ligand Activity Positive Regulation Of Immune Response To Tumor Cell Cell-cell Contact Zone Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Cell-cell Adhesion Adherens Junction Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Establishment Of Protein Localization To Membrane Negative Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Negative Regulation Of Defense Response Membrane Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Lactosylceramide Biosynthetic Process Regulation Of Transcytosis TRNA-guanosine(34) Queuine Transglycosylase Activity TRNA Wobble Guanine Modification TRNA-guanine Transglycosylase Complex