PVRL4 and TIGIT

Number of citations of the paper that reports this interaction (PMID 21982860)
4

Data Source:
BioGRID (pull down)

		PVRL4	TIGIT
Gene Name		poliovirus receptor-related 4	T cell immunoreceptor with Ig and ITIM domains
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding	Receptor Binding Protein Binding
	Biological Process	Cell Adhesion Viral Process Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MLLT4 PICK1 PVRL1 PVRL2 TIGIT	4 interactors: PVR PVRL2 PVRL3 PVRL4
Entrez ID		81607	201633
HPRD ID		17934	08804
Ensembl ID		ENSG00000143217	ENSG00000181847
Uniprot IDs		K4PZ75 Q96NY8	Q495A1
PDB IDs		4FRW 4GJT 4JJH	3Q0H 3RQ3 3UCR 3UDW
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Viral Entry Into Host Cell Entry Into Host Cell Cell Development Interaction With Host Coreceptor-mediated Virion Attachment To Host Cell Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Fusion Of Virus Membrane With Host Plasma Membrane Viral Life Cycle Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Projection Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Cell Adhesion Establishment Of Endothelial Intestinal Barrier Enamel Mineralization Virion Attachment To Host Cell DNA Methylation Involved In Embryo Development Positive Regulation Of Immune Response To Tumor Cell Dendritic Spine Maintenance Adhesion Of Symbiont To Host Cell Differentiation Tooth Mineralization Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Desmosome Organization Positive Regulation Of Mast Cell Activation Negative Regulation Of Actin Nucleation Acrosome Assembly Amelogenesis Establishment Of Mitochondrion Localization Positive Regulation Of Rap GTPase Activity Long Term Synaptic Depression Regulation Of Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Component Assembly Negative Regulation Of Interleukin-12 Production Dendritic Spine Organization Regulation Of Rap GTPase Activity DNA Methylation Involved In Gamete Generation	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Viral Entry Into Host Cell Entry Into Host Cell Cellular Component Assembly Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of Adaptive Immune Response Fertilization Sperm Mitochondrion Organization Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Adaptive Immune Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Fusion Of Virus Membrane With Host Plasma Membrane Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Response To Virus Virion Attachment To Host Cell Adhesion Of Symbiont To Host Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Single Organismal Cell-cell Adhesion Positive Regulation Of Immune Response Spermatid Nucleus Differentiation Lens Morphogenesis In Camera-type Eye Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization
Tagcloud ?			abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely pvr recruit restoration ship1 tail terminate tyr225
Tagcloud (Difference) ?			abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely pvr recruit restoration ship1 tail terminate tyr225
Tagcloud (Intersection) ?