CAMK2B and MVP

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		CAMK2B	MVP
Description		calcium/calmodulin dependent protein kinase II beta	major vault protein
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Cell Differentiation Protein Autophosphorylation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Protein Localization To Plasma Membrane Regulation Of Neuron Migration	Cell Population Proliferation Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Neutrophil degranulation
Drugs		[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases
GWAS		Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Fasting glucose ( 34059833) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) Two-hour glucose ( 34059833)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		58 interacting genes: ACOT7 ACTN4 ARSA ATXN1 CAMK2D CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 FMR1 FXR1 FXR2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP NCOR2 PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SHANK3 SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5	69 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP HSPA13 IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF10 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2
Entrez ID		816	9961
HPRD ID		12127	05475
Ensembl ID		ENSG00000058404	ENSG00000013364
Uniprot IDs		A4D2J9 B7Z1Z6 Q13554	Q14764 X5D2M8 X5D7K9 X5DNU0
PDB IDs		3BHH 7URW 7URY 7URZ	1Y7X 9BW5 9BW6 9BW7 9MXH 9MXV
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intermediate Filament Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Strand Annealing Activity Positive Regulation Of Neurogenesis Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Synaptic Transmission Neuron Projection Dendritic Spine Regulation Of RNA Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Membraneless Organelle NMDA Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Dendritic Spine Development Poly(G) Binding Positive Regulation Of Nervous System Development Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Metabolic Process Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Regulation Of Macromolecule Metabolic Process Molecular Condensate Scaffold Activity Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Ubiquitin-protein Transferase Activity Protein Binding Glutamate Receptor Signaling Pathway Regulation Of Nervous System Process	Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Biosynthetic Process Cytoplasm Regulation Of Neurogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity PML Body Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nervous System Development Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Regulation Of Neuronal Synaptic Plasticity TFIIB-class Transcription Factor Binding Viral Penetration Into Host Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase Benzodiazepine Receptor Binding Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Strand Annealing Activity Regulation Of MiRNA-mediated Gene Silencing Somite Specification Dentate Gyrus Development Single-stranded Telomeric DNA Binding MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Viral Process Protein Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chromosome Organization Positive Regulation Of Neurogenesis Intracellular Membraneless Organelle Presynapse Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process
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