CAMK2B and KRTAP10-11

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CAMK2B	KRTAP10-11
Description		calcium/calmodulin dependent protein kinase II beta	keratin associated protein 10-11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Cell Differentiation Protein Autophosphorylation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Protein Localization To Plasma Membrane Regulation Of Neuron Migration
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Keratinization Keratinization
Drugs		[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases
GWAS		Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Fasting glucose ( 34059833) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) Two-hour glucose ( 34059833)
Interacting Genes		58 interacting genes: ACOT7 ACTN4 ARSA ATXN1 CAMK2D CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 FMR1 FXR1 FXR2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP NCOR2 PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SHANK3 SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5	63 interacting genes: ADAMTSL4 ANKS1A C22orf39 CAMK2B CATSPER1 CRCT1 CREB5 CYSRT1 FAM76B FBXO34 GLRX3 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-2 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A MEOX2 MOBP NBPF19 NOTCH2NLA NUFIP2 OTX1 PLSCR1 POU4F2 PRKAB2 PRKAG1 SMCP SPATA3 SPRY1 SPRY2 TLE5 ZNF587
Entrez ID		816	386678
HPRD ID		12127	11186
Ensembl ID		ENSG00000058404	ENSG00000243489
Uniprot IDs		A4D2J9 B7Z1Z6 Q13554	P60411 P60412
PDB IDs		3BHH 7URW 7URY 7URZ
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intermediate Filament Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Strand Annealing Activity Positive Regulation Of Neurogenesis Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Synaptic Transmission Neuron Projection Dendritic Spine Regulation Of RNA Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Membraneless Organelle NMDA Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Dendritic Spine Development Poly(G) Binding Positive Regulation Of Nervous System Development Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Metabolic Process Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Regulation Of Macromolecule Metabolic Process Molecular Condensate Scaffold Activity Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Ubiquitin-protein Transferase Activity Protein Binding Glutamate Receptor Signaling Pathway Regulation Of Nervous System Process	Keratinization Intermediate Filament Epidermis Development Keratin Filament Tissue Development Hair Cycle Identical Protein Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation AMP-activated Protein Kinase Activity Protein Binding Bud Elongation Involved In Lung Branching Developmental Process Regulation Of Lens Fiber Cell Differentiation Nucleotide-activated Protein Kinase Complex Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?